色素沉着绒毛结节性滑膜炎中人类滑膜衬里细胞的代谢改变
Metabolic alterations in human synovial lining cells in pigmented villonodular synovitis.
作者信息
Henderson B, Bitensky L, Johnstone J J, Catterall A, Chayen J
出版信息
Ann Rheum Dis. 1979 Oct;38(5):463-6. doi: 10.1136/ard.38.5.463.
Abstract
Synovial tissue from 3 patients with villonodular synovitis has been examined by quantitative cytochemistry. Considerable changes in the metabolism of the synoviocytes have been observed. These included a massive rise in the activity of glucose 6-phosphate dehydrogenase to levels even greater than those found in rheumatoid arthritis, and a significant rise in the activity of 2 glycolytic enzymes, glyceraldehyde 3-phosphate and lactate dehydrogenase. Lysosomal napthhylamidase showed raised activity with no latency. The sulphydryl content in the synoviocytes was raised, as was the amount of available phospholipid. This pattern of metabolic alterations is similar to that found in human rheumatoid synoviocytes.
摘要
对3例绒毛结节性滑膜炎患者的滑膜组织进行了定量细胞化学检查。已观察到滑膜细胞代谢有显著变化。这些变化包括6-磷酸葡萄糖脱氢酶活性大幅升高，甚至高于类风湿性关节炎患者的水平，以及两种糖酵解酶（磷酸甘油醛和乳酸脱氢酶）的活性显著升高。溶酶体萘基酰胺酶活性升高且无潜伏期。滑膜细胞中的巯基含量增加，可用磷脂的量也增加。这种代谢改变模式与人类类风湿滑膜细胞中的情况相似。
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