Marigo M, Ferrara S D, Cima L, Giusti P, Floreani M
Arch Toxicol. 1979 Sep;42(4):295-301. doi: 10.1007/BF00334844.
Isoaminile (Peracon) has found in Italy a certain success as a substitute for hard narcotcis. Three observations are reported in which five young adults have been intoxicated by the i.v. administration of the cough suppressant. On the basis of two opposed points of view suggested by the Literature to explain the compulsive abuse of this drug, the A. have studied its physical dependence capacity by using an original technique. The isoaminile cyanide release has been measured too. The experimental results demonstrate that isoaminile does not determine a physical dependence; a slight CN- release activity occurs in vivo only with high doses.
异米尼尔（哌醋甲酯）在意大利作为硬性麻醉药的替代品已取得一定成功。报告了3例观察病例，其中5名年轻人因静脉注射这种止咳药而中毒。根据文献中提出的两种相反观点来解释这种药物的强迫性滥用，作者采用一种原始技术研究了其身体依赖性能力。还测定了异米尼尔的氰化物释放量。实验结果表明，异米尼尔不会产生身体依赖性；仅在高剂量时体内才会出现轻微的氰离子释放活性。
