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用XAD - 4树脂血液灌流治疗重度对硫磷中毒(作者译)

[Hemoperfusion with XAD-4 resin in the treatment of a severe parathion intoxication (author's transl)].

作者信息

Pentz R, Brunn J

出版信息

Arch Toxicol. 1979 Sep;42(4):311-5. doi: 10.1007/BF00334846.

DOI:10.1007/BF00334846
PMID:518296
Abstract

After ingestion of 200-300 ml E 605-forte (i.e., 100-150 g parathion) a maximal concentration of 10.2 mg/l could be measured in the plasma of a male patient. An extracorporeal hemoperfusion was carried out using XAD-4 resin. The clearance valued 83 ml/min at a blood flow of 100 ml/min, which is about 40% higher compared to perfusion on activated charcoal. The described method is possibly an improved technique which could raise the rate of survival following parathion intoxication. In our study, however, the fatal end could not be prevented due to the intake of a very high dose of the poison.

摘要

摄入200 - 300毫升E 605 - forte(即100 - 150克对硫磷)后,一名男性患者血浆中可测得的最大浓度为10.2毫克/升。使用XAD - 4树脂进行了体外血液灌流。在血流量为100毫升/分钟时,清除率为83毫升/分钟,这比用活性炭进行灌流时高出约40%。所描述的方法可能是一种改进技术,可提高对硫磷中毒后的生存率。然而,在我们的研究中,由于摄入了非常高剂量的毒物,未能防止致命结局。

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引用本文的文献

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Arch Toxicol. 1988 Jan;61(3):196-200. doi: 10.1007/BF00316634.

本文引用的文献

1
[Poisoning with E 605 (O, O-diethyl-O-p-nitrophenyl thiophosphoric acid ester); collective report on fatal cases published up to January 1, 1955 and 10 personal cases as well as theoretical bases of poisoning and detection methods].[E605(O,O - 二乙基 - O - 对硝基苯基硫代磷酸酯)中毒;截至1955年1月1日已发表的致命病例汇总报告、10例个人病例以及中毒的理论基础和检测方法]
Arch Toxikol. 1955;15(4-5):210-84.
2
Determination of acetylcholine, nitrostigmine and acetylcholinesterase activity in four patients with severe nitrostigmine (E 605 forte) intoxication.四名重度新斯的明(E 605 强效型)中毒患者体内乙酰胆碱、新斯的明及乙酰胆碱酯酶活性的测定
Arch Toxicol. 1974;32(2):97-108. doi: 10.1007/BF00316230.
3
Detection and determination of organophosphorus insecticides in tissues by thin-layer chromatography.
J Chromatogr. 1977 Jan 11;130:229-36. doi: 10.1016/s0021-9673(00)89799-x.
4
Probable progress in the therapy of organophosphate poisoning: extracorporeal hemodialysis and hemoperfusion.有机磷中毒治疗的可能进展:体外血液透析和血液灌流。
Arch Toxicol. 1976 Jun 8;35(3):221-7. doi: 10.1007/BF00293570.
5
Detection and assay of organophosphate pesticides in human blood by gas chromatography.气相色谱法检测和测定人血液中的有机磷农药
Clin Toxicol. 1978;12(4):457-62. doi: 10.3109/15563657809150016.
6
A rapid gas-chromatographic method for the determination of drugs in clinical toxicology.
Arch Toxicol. 1978 Jan 25;39(3):225-33. doi: 10.1007/BF00368231.
7
[Medicolegal aspects of poisoning (author's transl)].中毒的法医学问题(作者译)
Arch Toxicol. 1978 Jan 25;39(3):199-209. doi: 10.1007/BF00368228.
8
Hemoperfusion with coated activated charcoal in the treatment of organophosphate poisoning.用包被活性炭血液灌流治疗有机磷中毒
Acta Pharmacol Toxicol (Copenh). 1977;41 Suppl 2:85-90.