Windler E, Dreyer M, Runge M
Schweiz Med Wochenschr. 1983 Jun 11;113(23):861-2.
In a 41-year-old patient administration of 5 g parathion led to respiratory failure and unconsciousness. Ventilatory support and antidote therapy were initiated early. However, only extensive gastric lavage and lowering of the plasma concentration by hemoperfusion with activated carbon resulted in the crucial elimination of the poison. Antidote and supportive measures may overcome the hazards of cholinesterase-inhibition, but not the direct toxic effect on the cardiovascular system which is currently regarded as the predominant cause of death.
一名41岁患者摄入5克对硫磷后出现呼吸衰竭和昏迷。早期即开始进行通气支持和解毒治疗。然而,只有通过用活性炭进行血液灌流进行广泛洗胃并降低血浆浓度,才实现了关键的毒物清除。解毒剂和支持性措施可能会克服胆碱酯酶抑制的危害,但无法克服对心血管系统的直接毒性作用,目前认为这是主要的死亡原因。