Anghileri L J
Int J Clin Pharmacol Biopharm. 1975 Oct;12(3):320-6.
Ammonium chloride-induced metabolic acidosis decreases the growth of various experimental tumors. Spleen exhibits the same effects. There is a sex factor which seems to affect the growth of both tumor and spleen. The observed tumor inhibition appears to be related to a systemic impairment of the anabolic mechanisms. The decrease in tumor calcium suggests that this element may play a role in the tissue growth. The possible implication of cell membrane changes and of a block in glycolysis in the acidosis effects are discussed.
氯化铵诱导的代谢性酸中毒会减缓各种实验性肿瘤的生长。脾脏也有同样的作用。存在一个性别因素，似乎会影响肿瘤和脾脏的生长。观察到的肿瘤抑制作用似乎与合成代谢机制的全身性损害有关。肿瘤钙含量的降低表明该元素可能在组织生长中起作用。文中讨论了细胞膜变化以及酸中毒效应中糖酵解受阻的可能影响。
