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将行为不同的品系进行组合的嵌合小鼠的行为表现。

Behavior in chimeric mice combining differently behaving strains.

作者信息

Nesbitt M N, Spence M A, Butler K

出版信息

Behav Genet. 1979 Jul;9(4):277-87. doi: 10.1007/BF01068206.

DOI:10.1007/BF01068206
PMID:518467
Abstract

A/J and C57BL/6J mice behave differently in tests for alcohol preference, open-field activity, defecation in the open field, cricket attacking, and rope climbing. Chimeric mice, i.e., mice containing both A/J cells and C57BL/6J cells, were constructed and tested for these behaviors. Patterns of behavior among A/J in equilibrium with C57BL/6J chimeras are such as to suggest that none of these behavior differences is controlled by a single cell or clone and that the same cell population that gives rise to the strain difference in alcohol preference also gives rise to the differences in open-field activity and defecation, while separate cell populations control cricket killing and rope climbing.

摘要

在酒精偏好测试、旷场活动测试、旷场排便测试、攻击蟋蟀测试和爬绳测试中,A/J小鼠和C57BL/6J小鼠的行为表现不同。构建了嵌合小鼠,即同时含有A/J细胞和C57BL/6J细胞的小鼠,并对这些行为进行了测试。与C57BL/6J嵌合体处于平衡状态的A/J小鼠的行为模式表明,这些行为差异中没有一种是由单个细胞或克隆控制的,导致酒精偏好品系差异的同一细胞群体也导致了旷场活动和排便的差异,而不同的细胞群体控制着蟋蟀捕杀和爬绳行为。

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本文引用的文献

1
Mouse chimaeras developed from fused eggs.由融合卵发育而来的小鼠嵌合体。
Nature. 1961 Jun 3;190:857-60. doi: 10.1038/190857a0.
2
The genetics of mouse behavior in novel situations.
J Comp Physiol Psychol. 1959 Feb;52(1):62-7. doi: 10.1037/h0044664.
3
The inheritance of behaviour: behavioural differences in fifteen mouse strains.
Can J Psychol. 1953 Dec;7(4):145-55. doi: 10.1037/h0083586.
4
神经毒理学和神经药理学中的遗传因素:对遗传学作为研究工具应用的批判性评估。
Experientia. 1991 Oct 15;47(10):990-8. doi: 10.1007/BF01923334.
Isoenzymes of phosphoglucose isomerase in mice.
小鼠中的磷酸葡萄糖异构酶同工酶
Nature. 1967 Nov 4;216(5114):511. doi: 10.1038/216511a0.
5
Effects of the albino and dilute loci on mouse behavior.白化和稀释基因座对小鼠行为的影响。
J Comp Physiol Psychol. 1967 Apr;63(2):320-3. doi: 10.1037/h0024361.
6
Enzyme activities and ethanol preference in mice.
Biochem Genet. 1968 Nov;2(3):205-12. doi: 10.1007/BF01474759.
7
Predatory behavior in laboratory mice: strain and sex comparisons.
J Comp Physiol Psychol. 1973 Nov;85(2):243-9. doi: 10.1037/h0035008.
8
A model for estimating the extent of variegation in mosaic tissues.一种用于估计镶嵌组织中斑驳程度的模型。
J Theor Biol. 1973 Jan;38(1):61-79. doi: 10.1016/0022-5193(73)90225-7.
9
Ethanol consumption and preference in mice: a genetic analysis.小鼠的乙醇消耗与偏好:一项遗传学分析。
Ann N Y Acad Sci. 1972 May 25;197:42-8. doi: 10.1111/j.1749-6632.1972.tb28116.x.
10
Genetics as a tool in alcohol research.遗传学作为酒精研究中的一种工具。
Ann N Y Acad Sci. 1972 May 25;197:26-31. doi: 10.1111/j.1749-6632.1972.tb28114.x.