葡萄球菌的耐药性。VII. 对四环素、链霉素、磺胺和青霉素耐药的遗传决定因素。
Drug resistance of staphylococci. VII. Genetic determinants responsible for the resistance to tetracycline, streptomycin, sulfanilamide, and penicillin.
作者信息
Kasuga T, Hashimoto H, Mitsuhashi S
出版信息
J Bacteriol. 1968 May;95(5):1764-6. doi: 10.1128/jb.95.5.1764-1766.1968.
A genetic analysis of resistance to tetracycline (TC), streptomycin (SM), sulfanilamide (SA), and penicillin G was carried out through transduction with phage lysates obtained from a multiply resistant strain of Staphylococcus aureus by ultraviolet irradiation. All transductants acquired resistance to both TC and SA, even when singly selected for either SA or TC resistance. The locus responsible for TC resistance could not be separated genetically from that for SA resistance. On the other hand, in transduction of SM resistance, about 30% of the transductants jointly acquired resistance to both TC and SA. These observations suggest that the loci governing resistance to TC, SA, and SM exist close together on a single genetic unit, this probably being the chromosome.
通过用紫外线照射从一株多重耐药金黄色葡萄球菌获得的噬菌体裂解物进行转导，对四环素（TC）、链霉素（SM）、磺胺（SA）和青霉素G的耐药性进行了遗传分析。所有转导子都获得了对TC和SA的耐药性，即使是单独选择对SA或TC耐药的转导子也是如此。负责TC耐药性的基因座在遗传上不能与负责SA耐药性的基因座分开。另一方面，在转导SM耐药性时，约30%的转导子同时获得了对TC和SA的耐药性。这些观察结果表明，控制对TC、SA和SM耐药性的基因座在一个单一的遗传单位上紧密相邻，这可能就是染色体。
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