Murray F S, Weaver M M
J Comp Physiol Psychol. 1975 Sep;89(7):819-26. doi: 10.1037/h0077028.
The experimental study of itch was reviewed, and an experiment performed to test the effects of ipsilateral and contralateral counterirritation distal to the itching wrist. Each of the 18 subjects served in all experimental conditions, receiving cowage as the itch stimulus and a placebo. Counterirritation consisted of a 10-sec immersion of the fingers into a 2 degrees C water bath. Lateral differences both in response to cowage and to counterirritation were obtained. In general, counterirritation reduced itch significantly more than the control procedure during the treatment period and the first three intervals following treatment. The results of the present experiment suggest a central mechanism attenuating the sensation of itch.
对瘙痒的实验研究进行了综述，并开展了一项实验，以测试在瘙痒手腕远端进行同侧和对侧反刺激的效果。18名受试者参与了所有实验条件，接受刺蒴麻作为瘙痒刺激物和一种安慰剂。反刺激包括将手指浸入2摄氏度的水浴中10秒。获得了对刺蒴麻和反刺激的横向差异。一般来说，在治疗期间和治疗后的前三个时间段内，反刺激比对照程序更能显著减轻瘙痒。本实验结果提示存在一种减轻瘙痒感觉的中枢机制。
