Ekblom A, Fjellner B, Hansson P
Acta Physiol Scand. 1984 Nov;122(3):361-7. doi: 10.1111/j.1748-1716.1984.tb07520.x.
The effect of conditioning mechanical vibratory stimulation and transcutaneous electrical nerve stimulation (TENS) on experimentally induced pruritus was studied on 12 healthy subjects. Pruritus was provoked by intradermal injection of histamine on the upper arm. Vibration at 10, 100 and 200 Hz and TENS at 2 and 100 Hz were applied (i) over or (ii) proximal (in the same dermatome) to the pruritic area for a period of 5 min following itch elicitation. In addition the influence of a 5 min pre-stimulatory regimen of the injection area was investigated (iii). The results obtained were compared with unconditioned values and with those obtained following a placebo conditioning procedure (i, ii). It was found that vibratory as well as electrical stimulation, for all frequencies used, reduced subjective itch intensity. Vibration at 100 Hz was the most effective mode of stimulation especially when applied directly to the pruritic area. Conditioning with 100 Hz vibration was also the most effective mode for reducing the duration of the itch response as well as the total experience of pruritus (estimated as a total itch index). Induction time to partial and maximal itch alleviation was shortest for 100 Hz vibration. The results indicate that treatment of pruritic conditions with conditioning stimulation, especially vibration, may be of therapeutic interest.
在12名健康受试者身上研究了条件性机械振动刺激和经皮电刺激神经疗法（TENS）对实验性诱发瘙痒的影响。通过在上臂皮内注射组胺诱发瘙痒。在诱发瘙痒后，将10、100和200赫兹的振动以及2和100赫兹的TENS分别（i）施加于瘙痒区域上方或（ii）近端（在同一皮节），持续5分钟。此外，还研究了对注射区域进行5分钟预刺激方案的影响（iii）。将获得的结果与未进行条件刺激的值以及安慰剂条件刺激程序（i、ii）后获得的结果进行比较。结果发现，对于所有使用的频率，振动以及电刺激均降低了主观瘙痒强度。100赫兹的振动是最有效的刺激方式，尤其是直接施加于瘙痒区域时。用100赫兹振动进行条件刺激也是减少瘙痒反应持续时间以及瘙痒总体体验（估计为总瘙痒指数）的最有效方式。对于100赫兹的振动，达到部分和最大瘙痒缓解的诱导时间最短。结果表明，用条件刺激尤其是振动来治疗瘙痒状况可能具有治疗价值。
