Nakao J, Orimo H, Ooyama T, Shiraki M
Atherosclerosis. 1979 Dec;34(4):469-74. doi: 10.1016/0021-9150(79)90071-6.
The relationship between arterial calcification and serum estradiol levels was studied in 72 postmenopausal female and 59 male subjects. In both sexes, subjects with iliac artery calcification had rather lower serum estradiol levels (8.4 +/- 1.4 pg/ml in the females, and 19.2 +/- 2.5 pg/ml in the males) than controls (16.1 +/- 1.6 pg/ml in the females, and 29.7 +/- 2.4 pg/ml in the males). The bone mineral content of females with iliac artery calcification (0.44 +/- 0.02 g/cm2) was lower than controls (0.52 +/- 0.01 g/cm2); a positive correlation between serum estradiol levels and bone mineral content was found in the females. However, bone mineral content did not significantly differ between males with and without arterial calcification (0.67 +/- 0.03 g/cm2 in the former, and 0.65 +/- 0.02 g/cm2 in the latter). These results indicate that arterial calcification and increased bone resorption are both individual results of estrogen deficiency.
在72名绝经后女性和59名男性受试者中研究了动脉钙化与血清雌二醇水平之间的关系。在男女两性中，有髂动脉钙化的受试者血清雌二醇水平（女性为8.4±1.4 pg/ml，男性为19.2±2.5 pg/ml）均低于对照组（女性为16.1±1.6 pg/ml，男性为29.7±2.4 pg/ml）。有髂动脉钙化的女性骨矿物质含量（0.44±0.02 g/cm²）低于对照组（0.52±0.01 g/cm²）；在女性中发现血清雌二醇水平与骨矿物质含量呈正相关。然而，有和没有动脉钙化的男性之间骨矿物质含量没有显著差异（前者为0.67±0.03 g/cm²，后者为0.65±0.02 g/cm²）。这些结果表明，动脉钙化和骨吸收增加都是雌激素缺乏的个体结果。
