人血浆α1-酸性糖蛋白第一个糖基化位点去唾液酸碳水化合物单元的一级结构。
The primary structure of the asialo-carbohydrate units of the first glycosylation site of human plasma alpha 1-acid glycoprotein.
作者信息
Schmid K, Binette J P, Dorland L, Vliegenthart J F, Fournet B, Montreuil J
出版信息
Biochim Biophys Acta. 1979 Dec 14;581(2):356-9. doi: 10.1016/0005-2795(79)90255-1.
The elucidation of the structures of the carbohydrate units linked to glycosylation site I of human plasma alpha 1-acid glycoprotein is described. These carbohydrate units can be grouped into compounds with bi- (class A) and triantennary (class B) structures and the triantennary structure with a fucose residue (class BF) (Fig. 1). The structural variability of the carbohydrate units of glycosylation site I and also of glycosylation sites II to V (Fournet, B., Montreuil, J., Strecker, G., Dorland, L., Haverkamp, J., Vliegenthart, J.F.G., Binette, J.P. and Schmid, K. (1978) Biochemistry 17, 5206--5214) accounts largely for the microheterogeneity of alpha 1-acid glycoprotein.
本文描述了与人类血浆α1-酸性糖蛋白糖基化位点I相连的碳水化合物单元结构的阐明。这些碳水化合物单元可分为具有双天线（A类）和三天线（B类）结构的化合物，以及带有岩藻糖残基的三天线结构（BF类）（图1）。糖基化位点I以及糖基化位点II至V的碳水化合物单元的结构变异性（Fournet, B., Montreuil, J., Strecker, G., Dorland, L., Haverkamp, J., Vliegenthart, J.F.G., Binette, J.P. 和 Schmid, K. (1978) Biochemistry 17, 5206--5214）在很大程度上解释了α1-酸性糖蛋白的微观异质性。
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