α-辅肌动蛋白、细丝蛋白和原肌球蛋白与丝状肌动蛋白的相互作用。
Interaction of alpha-actinin, filamin and tropomyosin with F-actin.
作者信息
Zeece M G, Robson R M, Bechtel P J
出版信息
Biochim Biophys Acta. 1979 Dec 14;581(2):365-70. doi: 10.1016/0005-2795(79)90258-7.
PMID:518922
Abstract
The abilities of alpha-actinin, filamin and tropomyosin to bind F-actin were examined by cosedimentation experiments. Results indicated that smooth muscle alpha-actinin and filamin can bind to actin filaments simultaneously with little evidence of competition. In contrast, tropomyosin exhibits marked competition with either filamin or alpha-actinin for sites on actin filaments.
摘要
通过共沉降实验检测了α-辅肌动蛋白、细丝蛋白和原肌球蛋白与F-肌动蛋白结合的能力。结果表明，平滑肌α-辅肌动蛋白和细丝蛋白能够同时与肌动蛋白丝结合，几乎没有竞争迹象。相比之下，原肌球蛋白在肌动蛋白丝上的结合位点与细丝蛋白或α-辅肌动蛋白存在明显竞争。
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