Brock D J, Scrimgeour J B, Bolton A E, Wald N, Peto R, Barker S
Lancet. 1975 Aug 2;2(7927):195-6. doi: 10.1016/s0140-6736(75)90669-8.
Maternal plasma or serum alpha-feto-protein (A.F.P.) concentrations were measured once between 8 and 22 weeks of gestation in each of sixty-two pregnancies which resulted in an infant with a neural-tube defect. Between 13 and 22 weeks of pregnancy twenty-two of the forty-one cases tested (54%) had A.F.P. values greater than three times the median value for unaffected pregnancies (which is equivalent to the 97th percentile of normal), and many of these values were very high indeed. However, before the 13th week of pregnancy only one of the twenty-one cases (5%) had an A.F.P. value more than three times the median for unaffected pregnancies, and this value was not very high. This indicates that in antenatal screening for anencephaly or spina bifida, A.F.P. should be measured in blood taken from the mother during the second trimester.
对62例怀有神经管缺陷婴儿的孕妇，在妊娠8至22周期间均测量了一次母血或母血清中甲胎蛋白（A.F.P.）的浓度。在妊娠13至22周期间，41例接受检测的病例中有22例（54%）的A.F.P.值高于未受影响妊娠中位数的3倍（相当于正常水平的第97百分位数），而且其中许多值确实非常高。然而，在妊娠13周之前，21例病例中只有1例（5%）的A.F.P.值超过未受影响妊娠中位数的3倍，且该值并非很高。这表明，在产前筛查无脑儿或脊柱裂时，应在孕中期采集的母血中测量A.F.P.。
