Leighton P C, Kitau M J, Chard T, Gordon Y B, Leek A E
Lancet. 1975 Nov 22;2(7943):1012-5. doi: 10.1016/s0140-6736(75)90295-0.
A range has been established for maternal plasma-alpha-fetoprotein (A.F.P.) levels in normal pregnancies (930 women). A.F.P. levels between 10 and 40 weeks gestation were examined in 51 pregnancies associated with fetal neural-tube defect. In 96% of cases (20 anencephalus, 6 spina bifida) examined between 16 and 26 weeks of gestation A.F.P. levels were above the 95th centile of the normal range. It is suggested that measurement of A.F.P. in maternal blood should become a screening test in all pregnancies, and a scheme for the futher investigation of patients with abnormal results is described.
已确定正常妊娠（930名女性）母体血浆甲胎蛋白（A.F.P.）水平的范围。对51例与胎儿神经管缺陷相关的妊娠进行了妊娠10至40周期间A.F.P.水平的检测。在妊娠16至26周期间检测的96%的病例（20例无脑儿、6例脊柱裂）中，A.F.P.水平高于正常范围的第95百分位数。建议母体血液中A.F.P.的检测应成为所有妊娠的筛查试验，并描述了对结果异常患者进行进一步检查的方案。
