Farthing S, Peronneau P
Cardiovasc Res. 1979 Nov;13(11):607-20. doi: 10.1093/cvr/13.11.607.
Pulsed ultrasonic Doppler velocimetry and theoretical flow analysis have been combined to improve the knowledge and understanding of aortic velocity profiles and wall shear. From the theoretical point of view, particular aspects of the flow were developed, concerning the vorticity in the aorta, the interior velocity distribution, the boundary layer, the flow after separation and the effects of the branches. The experimental approach was performed on dogs, using pulsed ultrasonic Doppler velocimeter providing real-time acquisition of the instantaneous velocity distribution along vascular diameters and perivascular probes designed for bidimensional measurement of velocity distribution. The good agreement found between theory and the experimental velocity profiles has led to comparison of the assessments of axial shear. The peak of the measured shear agrees well with the calculated one; the largest observed shear, obtained at the level of the initial part of the descending thoracic aorta, varies from 4.5 Pa to 7.5 Pa depending on the cardiac output. Finally initial attempts have been made to correlate atheromatous wall lesion localisation with the flow and shear variation.
脉冲超声多普勒测速技术与理论血流分析相结合,以增进对主动脉速度剖面和壁面切应力的认识和理解。从理论角度出发,对血流的特定方面进行了研究,涉及主动脉中的涡度、内部速度分布、边界层、分离后的血流以及分支的影响。实验方法是在狗身上进行的,使用脉冲超声多普勒测速仪实时采集沿血管直径的瞬时速度分布,并使用为二维速度分布测量设计的血管周围探头。理论与实验速度剖面之间的良好一致性使得能够对轴向切应力的评估进行比较。测量的切应力峰值与计算值吻合良好;在胸降主动脉起始部水平获得的最大观察切应力,根据心输出量的不同,在4.5帕至7.5帕之间变化。最后,已经初步尝试将动脉粥样硬化壁病变的定位与血流和切应力变化相关联。