Sheetz J H, Menaker L
Cell Tissue Res. 1979;203(2):321-9. doi: 10.1007/BF00237246.
The cellular mechanisms responsible for the structural and functional alterations produced in salivary glands by isoproterenol (ISP) were investigated. Postnatal rats were injected with ISP, and alterations in the structure and protein components of the submandibular glands were determined. Normal age-dependent protein patterns detected by electrophoresis are attributed to the biochemical and functional differentiation of proacinar and acinar secretory cells and correlate with structural changes in these cells. Structural changes induced by ISP involve the acinar cells without detectably altering terminal tubule cells. In addition, synthesis of a specific protein by the glands is enhanced by ISP treatment. By comparing protein patterns in the submandibular glands of control and treated rats, it was concluded that ISP increases synthesis of a specific salivary protein normally produced by proacinar cells during a limited period of glandular development. These results suggest that a neurally mediated regulaotry mechanism that becomes altered by ISP plays a role in normal salivary gland development.
研究了异丙肾上腺素（ISP）对唾液腺产生结构和功能改变的细胞机制。对出生后的大鼠注射ISP，并测定下颌下腺的结构和蛋白质成分的变化。通过电泳检测到的正常年龄依赖性蛋白质模式归因于前腺泡和腺泡分泌细胞的生化和功能分化，并与这些细胞的结构变化相关。ISP诱导的结构变化涉及腺泡细胞，而未检测到终末小管细胞有改变。此外，ISP处理可增强腺体中一种特定蛋白质的合成。通过比较对照大鼠和处理大鼠下颌下腺的蛋白质模式，得出结论：ISP增加了前腺泡细胞在腺体发育的有限时期内正常产生的一种特定唾液蛋白的合成。这些结果表明，一种被ISP改变的神经介导调节机制在正常唾液腺发育中起作用。
