从皮质醇增多症患者切除的人肾上腺中，由脱氧皮质酮体外生物合成18-羟基-11-脱氧皮质酮。

In vitro biosynthesis of 18-hydroxy-11-deoxycorticosterone from deoxycorticosterone by human adrenal glands removed from patients with hypercorticism.

作者信息

Touitou Y, Bogdan A, Luton J P

出版信息

Clin Endocrinol (Oxf). 1979 Jul;11(1):39-45. doi: 10.1111/j.1365-2265.1979.tb03044.x.

DOI:10.1111/j.1365-2265.1979.tb03044.x

PMID:519871

Abstract

The biosynthesis of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) was studied by in vitro incubations of human adrenals resected from patients with Cushing's syndrome, using deoxycorticosterone as precursor. 18-OH-DOC synthesis was similar in adrenals from normal subjects and in those derived from patients with different types of Cushing's syndrome (hyperplasia, adenoma, carcinoma). The in vitro addition of o,p'-DDD (5 x 10(-3) M) to an adrenocortical carcinoma incubation did not alter 18-OH-DOC biosynthesis. By contrast, treatment of the patient with o,p'-DDD prior to adrenalectomy resulted in a low production of 18-OH-DOC in vitro but only when cortisol synthesis was drastically decreased.

摘要

以脱氧皮质酮为前体，通过对从库欣综合征患者切除的人肾上腺进行体外孵育，研究了18-羟基-11-脱氧皮质酮（18-OH-DOC）的生物合成。正常受试者肾上腺以及来自不同类型库欣综合征（增生、腺瘤、癌）患者的肾上腺中18-OH-DOC的合成情况相似。在肾上腺皮质癌孵育体系中体外添加邻，对'-滴滴滴（5×10⁻³ M）不会改变18-OH-DOC的生物合成。相比之下，在肾上腺切除术前用邻，对'-滴滴滴治疗患者，仅在皮质醇合成大幅降低时，体外才会导致18-OH-DOC产量降低。