分泌11-脱氧皮质酮、18-羟基-11-脱氧皮质酮和醛固酮的肾上腺肿瘤。

Adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone.

作者信息

Toyoda Y, Mizukoshi M, Umemoto M, Kuchii M, Ueyama K, Tomimoto S, Baba A, Shima H, Nishio I, Masuyama Y

机构信息

Department of Internal Medicine, Arida Municipal Hospital, Wakayama.

出版信息

Intern Med. 1996 Feb;35(2):123-8. doi: 10.2169/internalmedicine.35.123.

DOI:10.2169/internalmedicine.35.123

PMID:8680100

Abstract

A case of adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone and aldosterone is reported. A 55-year-old woman had hypertension, hypokalemia, low plasma renin activity and an adrenal tumor. The plasma level of aldosterone was normal, and the levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were extremely high. After the tumor removal, the plasma level of aldosterone decreased and plasma levels of 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were normalized. The tumor was benign adenoma and the production of steroid hormones was under control of adrenocorticotropic hormone. The enzyme activity of 21-hydroxylation in the tumor was elevated and that of 11 beta-hydroxylation was decreased compared with the adjacent tissue.

摘要

报告了一例分泌11-脱氧皮质酮、18-羟基-11-脱氧皮质酮和醛固酮的肾上腺肿瘤病例。一名55岁女性患有高血压、低钾血症、低血浆肾素活性及肾上腺肿瘤。醛固酮血浆水平正常，而11-脱氧皮质酮和18-羟基-11-脱氧皮质酮水平极高。肿瘤切除后，醛固酮血浆水平下降，11-脱氧皮质酮和18-羟基-11-脱氧皮质酮血浆水平恢复正常。肿瘤为良性腺瘤，类固醇激素的分泌受促肾上腺皮质激素控制。与相邻组织相比，肿瘤中21-羟化酶活性升高，11β-羟化酶活性降低。