Macaron C, Kyncl M, Singh S P
Clin Endocrinol (Oxf). 1979 Oct;11(4):371-5. doi: 10.1111/j.1365-2265.1979.tb03088.x.
Effects of acute intravenous administration of cimetidine on serum levels or PRL, TSH, LH and FSH were investigated in six healthy euthyroid, five hypothyroid and five hyperthyroid patients. Cimetidine failed to alter serum TSH levels in the hypothyroid patients. There was no change in LH and FSH levels except in two euthyroid subjects in whom significant rise in LH occurred. However, in all subjects, whether euthyroid, hypo- or hyperthyroid, the serum PRL concentration increased two to three fold above basal levels. The peak levels of serum PRL occurred at 15 min following the drug administration. The response was not blunted in the older age group. We conclude that unlike the TRH-mediated PRL release, the cimetidine-induced PRL release is independent of the levels of thyroid hormone.
在6名甲状腺功能正常的健康受试者、5名甲状腺功能减退患者和5名甲状腺功能亢进患者中，研究了静脉注射西咪替丁对血清催乳素（PRL）、促甲状腺激素（TSH）、促黄体生成素（LH）和促卵泡激素（FSH）水平的影响。西咪替丁未能改变甲状腺功能减退患者的血清TSH水平。除了两名甲状腺功能正常的受试者促黄体生成素水平显著升高外，LH和FSH水平没有变化。然而，在所有受试者中，无论甲状腺功能正常、减退还是亢进，血清PRL浓度均比基础水平升高了两到三倍。血清PRL的峰值出现在给药后15分钟。老年组的反应并未减弱。我们得出结论，与促甲状腺激素释放激素（TRH）介导的PRL释放不同，西咪替丁诱导的PRL释放与甲状腺激素水平无关。
