Cream J J, Olaisen B, Teisberg P, Soler A V, Thompson R A
Clin Genet. 1979 Nov;16(5):297-300. doi: 10.1111/j.1399-0004.1979.tb01005.x.
A study of the family of a patient who had an SLE-like syndrome and an extremely low serum C4 revealed an inheritance of C4 types and HLA region markers which indicated that the patient had 60--70% of "normal" C4 level prior to the onset of disease. Thus the extremely low C4 level during her disease may result from a combination of genetically determined low normal C4 and increased consumption/hyposynthesis secondary to her SLE.
