Lancet. 1975 Oct 4;2(7936):624-6.
341 patients with acute myocardial infarction have been treated in intensive or coronary care units. They were randomised into two groups, 172 receiving urokinase and 169 receiving a glucose infusion. Thereafter they were anticoagulated first with heparin and then for a year with oral anticoagulants. Despite a significantly faster regression of electrocardiographic alterations in the urokinase group there was no difference in mortality during the 1-year follow-up (29 deaths in the urokinase and 24 in the control group) and no difference in cardiac functional class between both groups.
341例急性心肌梗死患者在重症监护病房或冠心病监护病房接受了治疗。他们被随机分为两组，172例接受尿激酶治疗，169例接受葡萄糖输注。此后，他们首先用肝素进行抗凝治疗，然后用口服抗凝剂进行为期一年的治疗。尽管尿激酶组心电图改变的消退明显更快，但在1年的随访期间死亡率没有差异（尿激酶组29例死亡，对照组24例死亡），两组之间的心功能分级也没有差异。
