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引用本文的文献

1

The effect of once daily beta-adrenoceptor blocker-thiazide diuretic combination on the ambulatory blood pressure.

Br J Clin Pharmacol. 1982 Dec;14(6):827-31. doi: 10.1111/j.1365-2125.1982.tb02044.x.

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对中度高血压患者联合使用吲哚洛尔和氯噻酰胺（“Viskaldix”）进行的两年研究。

Two-years' study with a combination of pindolol and clopamide ('Viskaldix') in patients with moderate hypertension.

作者信息

Török E, Wagner M, Erdélyi M, Maklári E

出版信息

Curr Med Res Opin. 1979;6(3):193-200. doi: 10.1185/03007997909109420.

DOI:10.1185/03007997909109420

Abstract

A study was carried out to evaluate the long-term effects and side-effects of a combination product containing the beta-blocker pindolol (10 mg) and the diuretic clopamide (5 mg) in 15 patients with moderate hypertension. All patients completed the 2-years' study. The dose of the combination was increased until blood pressure normalized or a maximum dose of 3 tablets (equivalent to 30 mg pindolol and 15 mg clopamide) daily was reached. Blood pressure and heart rate were recorded monthly and detailed medical examinations were done regularly throughout the study. A mean dose of 2 tablets of the combination product (20 mg pindolol and 10 mg clopamide) produced a significant reduction in blood pressure. In all but 1 patient, blood pressure control was achieved and maintained. No tolerance developed. Heart volume showed a marked decrease. No side-effects of clinical importance were noted.

摘要

开展了一项研究，以评估一种含有β受体阻滞剂吲哚洛尔（10毫克）和利尿剂氯噻酮（5毫克）的复方制剂对15例中度高血压患者的长期疗效和副作用。所有患者均完成了为期两年的研究。复方制剂的剂量逐渐增加，直至血压恢复正常或达到每日最大剂量3片（相当于30毫克吲哚洛尔和15毫克氯噻酮）。在研究过程中，每月记录血压和心率，并定期进行详细的体格检查。平均每日服用2片复方制剂（20毫克吲哚洛尔和10毫克氯噻酮）可使血压显著降低。除1例患者外，所有患者的血压均得到控制并维持稳定。未产生耐受性。心脏体积显著减小。未发现具有临床意义的副作用。