Asplund J, Danielson M, Ohman P
Br J Clin Pharmacol. 1984 May;17(5):547-52. doi: 10.1111/j.1365-2125.1984.tb02388.x.
The importance of number of tablets for patient compliance was investigated in 160 patients with mild-moderate essential hypertension treated with a beta-adrenoceptor blocker and a thiazide diuretic. Mean BP at entry 146 +/- 16/92 +/- 8 mm Hg. All patients were given pindolol 10 mg and clopamide 5 mg in one combination tablet or in separate tablets for 4 months respectively. Approximately 90% of the patients took greater than 90% of the prescribed dose throughout the study. Mean BP decreased progressively and heart rate increased slightly. Side effects were more frequently reported during the first month of the study than previously, and 30 patients discontinued the treatment. No differences in this respect were seen between 1 and 2 tablets daily. Approximately 75% of the patients preferred 1 tablet daily, but combining two drugs in one tablet had no effect upon compliance.
在160例接受β-肾上腺素能受体阻滞剂和噻嗪类利尿剂治疗的轻中度原发性高血压患者中，研究了片剂数量对患者依从性的重要性。入组时平均血压为146±16/92±8 mmHg。所有患者分别服用含10 mg吲哚洛尔和5 mg氯噻酮的复方片剂或单独片剂，为期4个月。在整个研究过程中，约90%的患者服用了超过90%的规定剂量。平均血压逐渐下降，心率略有增加。与之前相比，研究第一个月报告的副作用更频繁，30例患者停止治疗。每日服用1片和2片在这方面没有差异。约75%的患者更喜欢每日服用1片，但将两种药物合为1片对依从性没有影响。
