Grekin D A, Zackheim H S, Epstein E H
Cutis. 1979 Nov;24(5):543-6.
Mycosis fungoides is a T-cell lymphoma which is often localized to the skin in the early stages. Untreated, the process eventually progresses through eczematous, plaque, and tumor stages to systemic involvement. Its course, however, is unpredictable. Topical chemotherapy is effective in early stages of mycosis fungoides. Possibly prognostic benefits can occur from the early use of these agents. Nitrogen mustard and BCNU, both alkylating agents, have been used topically to control the disease. A dermatitis may develop in persons treated with nitrogen mustard but systemic side-effects are rare. However, BCNU may rarely lead to marrow depression when used topically. The use of these agents in mycosis fungoides is discussed herein.
蕈样肉芽肿是一种T细胞淋巴瘤，在早期通常局限于皮肤。未经治疗，病情最终会经历湿疹期、斑块期和肿瘤期，进而发展为全身受累。然而，其病程是不可预测的。局部化疗在蕈样肉芽肿的早期有效。早期使用这些药物可能具有预后益处。氮芥和卡莫司汀这两种烷化剂已被局部用于控制该疾病。接受氮芥治疗的人可能会出现皮炎，但全身副作用很少见。然而，卡莫司汀局部使用时可能很少导致骨髓抑制。本文讨论了这些药物在蕈样肉芽肿中的应用。
