Tapsall J W, Taylor P C, Bell S M, Smith D D
Lancet. 1975 Oct 4;2(7936):637-9. doi: 10.1016/s0140-6736(75)90118-x.
28 of 74 female domiciliary patients who presented with urinary-tract symptoms did not fulfil the usually accepted laboratory criterion required for confirmation of urinary-tract infection (i.e., a urinary bacterial viable count in excess of 100 000/ml). The progress of the disease was similar in non-bacteriuric and bacteriuric patients. In addition, a significant proportion of the bacteriuric group did not show the response to therapy expected from the results of in-vitro tests of antibiotic sensitivity and urinary antibacterial activity. To explain these findings, it is postulated that bacteria may not be primary pathogens in uncomplicated urinary-tract infection even where "significant bacteriuria" is demonstrated.
74名出现泌尿系统症状的女性居家患者中，有28名未达到确诊泌尿系统感染通常所接受的实验室标准（即尿细菌活菌计数超过100000/ml）。非菌尿症患者和菌尿症患者的疾病进展相似。此外，相当一部分菌尿症患者对治疗的反应未达到体外抗生素敏感性试验和尿抗菌活性试验结果所预期的效果。为了解释这些发现，据推测，即使在证明有“显著菌尿”的情况下，细菌可能也不是单纯性泌尿系统感染的主要病原体。
