Ringe J D, Kuhlencordt F
Dtsch Med Wochenschr. 1979 Dec 28;104(52):1837-42. doi: 10.1055/s-0028-1129201.
33 monostotic and 27 polyostotic manifestations were found in 60 patients with Paget's disease of bone, 30 of whom were females (mean age 65.7 years) and 30 males (mean age 62.8 years). Pelvis, right tibia, lumbar spine, skull and sacrum were most commonly affected. Alkaline phosphatase activity in serum was raised in 95%, and in 88% hydroxyproline excretion in urine was increased. Due to the variable primary osseous or secondary arthrogenic complaints four groups could be distinguished among the monostotic cases. In polyostotic forms only some of the affected bones caused symptoms, whereas the other locations were only detected radiographically. The indication for calcitonin treatment of Paget's disease can only be made after in-patient investigation and evaluation of skeletal involvement, activity of the disease, complaints and assessment of complications actually present or to be expected according to the pattern of involvement. Under these conditions this form of treatment appeared indicated in 41 of 60 patients.
在60例骨佩吉特病患者中发现33例单骨型和27例多骨型表现，其中30例为女性（平均年龄65.7岁），30例为男性（平均年龄62.8岁）。骨盆、右胫骨、腰椎、颅骨和骶骨最常受累。95%的患者血清碱性磷酸酶活性升高，88%的患者尿羟脯氨酸排泄增加。由于原发性骨病或继发性关节病主诉各不相同，单骨型病例可分为四组。在多骨型中，只有部分受累骨骼出现症状，而其他部位仅通过影像学检查发现。只有在对患者进行住院检查并评估骨骼受累情况、疾病活动度、主诉以及根据受累模式对实际存在或预期的并发症进行评估后，才能确定是否对佩吉特病进行降钙素治疗。在这些条件下，60例患者中有41例似乎适合这种治疗方式。
