羟基多巴胺对吗啡诱导的脑内乙酰胆碱周转率降低的影响。
Effect of hydroxydopamine on the morphine-induced reduction in brain acetylcholine turnover.
作者信息
Slater P
出版信息
Experientia. 1979 Dec 15;35(12):1620-1. doi: 10.1007/BF01953228.
PMID:520475
Abstract
Morphine reduced brain acetylcholine turnover in normal and 6-hydroxydopamine-pretreated rats and mice. Morphine probably has a direct effect on cholinergic neurons rather than modifying acetylcholine indirectly through catecholamine neurons. Acetylcholine is not directly involved in morphine's antinociceptive action in the mouse but it could be implicated in the rat.
摘要
吗啡降低了正常及经6-羟基多巴胺预处理的大鼠和小鼠大脑中的乙酰胆碱周转率。吗啡可能对胆碱能神经元有直接作用，而非通过儿茶酚胺神经元间接改变乙酰胆碱。乙酰胆碱并不直接参与小鼠体内吗啡的镇痛作用，但可能与大鼠的镇痛作用有关。
Zotero 插件