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羟基多巴胺对吗啡诱导的脑内乙酰胆碱周转率降低的影响。

Effect of hydroxydopamine on the morphine-induced reduction in brain acetylcholine turnover.

作者信息

Slater P

出版信息

Experientia. 1979 Dec 15;35(12):1620-1. doi: 10.1007/BF01953228.

DOI:10.1007/BF01953228
PMID:520475
Abstract

Morphine reduced brain acetylcholine turnover in normal and 6-hydroxydopamine-pretreated rats and mice. Morphine probably has a direct effect on cholinergic neurons rather than modifying acetylcholine indirectly through catecholamine neurons. Acetylcholine is not directly involved in morphine's antinociceptive action in the mouse but it could be implicated in the rat.

摘要

吗啡降低了正常及经6-羟基多巴胺预处理的大鼠和小鼠大脑中的乙酰胆碱周转率。吗啡可能对胆碱能神经元有直接作用，而非通过儿茶酚胺神经元间接改变乙酰胆碱。乙酰胆碱并不直接参与小鼠体内吗啡的镇痛作用，但可能与大鼠的镇痛作用有关。

相似文献

1
Effect of hydroxydopamine on the morphine-induced reduction in brain acetylcholine turnover.羟基多巴胺对吗啡诱导的脑内乙酰胆碱周转率降低的影响。
Experientia. 1979 Dec 15;35(12):1620-1. doi: 10.1007/BF01953228.
2
The effect of 6-hydroxydopamine on the antinociceptive action of morphine.6-羟基多巴胺对吗啡镇痛作用的影响。
Eur J Pharmacol. 1978 Apr 1;48(3):237-47. doi: 10.1016/0014-2999(78)90082-1.
3
The effects of a permanent and selective depletion of brain catecholamines on the antinociceptive action of morphine.脑内儿茶酚胺永久性和选择性耗竭对吗啡镇痛作用的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):227-32. doi: 10.1007/BF00498815.
4
The effect of morphine on purine and acetylcholine release from rat cerebral cortex: evidence for a purinergic component in morphine's action.吗啡对大鼠大脑皮层嘌呤和乙酰胆碱释放的影响：吗啡作用中嘌呤能成分的证据。
Pharmacol Biochem Behav. 1980 Sep;13(3):421-7. doi: 10.1016/0091-3057(80)90249-x.
5
Morphine and methadone-induced antinociception in rats permanently depleted of brain dopamine.吗啡和美沙酮对永久性脑多巴胺耗竭大鼠的镇痛作用
Arch Int Pharmacodyn Ther. 1977 Oct;229(2):287-300.
6
Intravenous opioids stimulate norepinephrine and acetylcholine release in spinal cord dorsal horn. Systematic studies in sheep and an observation in a human.静脉注射阿片类药物可刺激脊髓背角去甲肾上腺素和乙酰胆碱的释放。在绵羊身上进行的系统研究以及在一名人类身上的观察。
Anesthesiology. 1996 Jan;84(1):143-54. doi: 10.1097/00000542-199601000-00017.
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Effect of morphine on catecholamine - stimulated cyclic AMP production in cortex slices from rats and mice.吗啡对大鼠和小鼠皮质切片中儿茶酚胺刺激的环磷酸腺苷生成的影响。
J Neurosci Res. 1981;6(6):701-8. doi: 10.1002/jnr.490060603.
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Antinociceptive and stimulant effects of morphine after chemical sympathectomy.化学性交感神经切除术后吗啡的镇痛和兴奋作用。
Pharmacology. 1976;14(3):265-73. doi: 10.1159/000136604.
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Potentiation of morphine-induced seizure by 6-hydroxydopamine.6-羟基多巴胺对吗啡诱发癫痫发作的增强作用。
Arch Int Pharmacodyn Ther. 1976 Oct;223(2):282-6.
10
Effects of morphine on the 6-hydroxydopamine induced changes of the postnatal development of central noradrenaline neurons.吗啡对6-羟基多巴胺诱导的中枢去甲肾上腺素能神经元产后发育变化的影响。
Med Biol. 1982 Aug;60(4):191-8.

本文引用的文献

1
DEPRESSION BY MORPHINE AND CHLORALOSE OF ACETYLCHOLINE RELEASE FROM THE CAT'S BRAIN.吗啡和水合氯醛对猫脑乙酰胆碱释放的抑制作用
J Physiol. 1965 Apr;177(3):411-9. doi: 10.1113/jphysiol.1965.sp007600.
2
A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain.一种将H3-去甲肾上腺素注入大鼠脑侧脑室的简单快速方法。
Life Sci. 1967 Feb 1;6(3):281-91. doi: 10.1016/0024-3205(67)90157-9.
3
Solvent extraction method for simultaneous determination of norepinephrine, dopamine, serotonin, and 5-hydroxyindoleacetic acid in a single mouse brain.
用于同时测定单只小鼠脑中去甲肾上腺素、多巴胺、5-羟色胺和5-羟基吲哚乙酸的溶剂萃取法
Anal Biochem. 1969 Aug;30(2):161-79. doi: 10.1016/0003-2697(69)90387-x.
4
The effects of triethylcholine and hemicholinium-3 on the acetylcholine content of rat brain.三乙胆碱和3-半胱氨酸对大鼠脑乙酰胆碱含量的影响。
Int J Neuropharmacol. 1968 Sep;7(5):421-7. doi: 10.1016/0028-3908(68)90041-5.
5
The effect of some drugs on the "free" and "bound" acetylcholine content of rat brain.某些药物对大鼠脑内“游离”和“结合”乙酰胆碱含量的影响。
Br J Pharmacol Chemother. 1968 May;33(1):42-7. doi: 10.1111/j.1476-5381.1968.tb00472.x.
6
Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine.用6-羟基多巴胺耗尽脑内去甲肾上腺素和多巴胺。
Br J Pharmacol. 1971 May;42(1):88-99. doi: 10.1111/j.1476-5381.1971.tb07089.x.
7
Relationship between acetylcholine content and release in the cat's cerebral cortex.猫大脑皮层中乙酰胆碱含量与释放之间的关系。
Can J Physiol Pharmacol. 1970 Nov;48(11):780-90. doi: 10.1139/y70-113.
8
Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.6-羟基多巴胺对脑去甲肾上腺素和多巴胺的影响：儿茶酚胺能神经元选择性变性的证据
J Pharmacol Exp Ther. 1970 Sep;174(3):413-20.
9
Lesions of central norepinephrine terminals with 6-OH-dopamine: biochemistry and fine structure.用6-羟基多巴胺对中枢去甲肾上腺素能终末的损伤：生物化学与精细结构
Science. 1969 Dec 5;166(3910):1284-6. doi: 10.1126/science.166.3910.1284.
10
Morphine catalepsy in the rat: relation to striatal dopamine metabolism.大鼠体内的吗啡僵住症：与纹状体多巴胺代谢的关系。
Eur J Pharmacol. 1972 Jul;19(1):119-22. doi: 10.1016/0014-2999(72)90086-6.