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两种新型催乳素释放抑制性8α-氨基麦角灵。

Two novel prolactin release-inhibiting 8 alpha-amino-ergolines.

作者信息

Flückiger E, Briner U, Bürki H R, Marbach P, Wagner H R, Doepfner W

出版信息

Experientia. 1979 Dec 15;35(12):1677-8. doi: 10.1007/BF01953267.

DOI:10.1007/BF01953267
PMID:520501
Abstract

Prolactin secretion inhibition and changes in striatal dopamine metabolism in rats were compared after the administration of 8 alpha-amino-ergoline CH 29-717 and 2 derivates. CQ 32-084 was similar to but less potent than CH 29-717, while 32-085, the l-methyl derivative, showed delayed dopaminomimetic effects.

摘要

在给予大鼠8α-氨基麦角灵CH 29-717及其2种衍生物后，比较了催乳素分泌抑制作用及纹状体多巴胺代谢的变化。CQ 32-084与CH 29-717相似，但效力较弱，而1-甲基衍生物32-085则表现出延迟的拟多巴胺效应。

相似文献

1
Two novel prolactin release-inhibiting 8 alpha-amino-ergolines.两种新型催乳素释放抑制性8α-氨基麦角灵。
Experientia. 1979 Dec 15;35(12):1677-8. doi: 10.1007/BF01953267.
2
Prolactin secretion inhibition by a new 8alpha-amino-ergoline, CH 29-171.新型8α-氨基麦角灵CH 29-171对催乳素分泌的抑制作用
Experientia. 1978 Oct 15;34(10):1330-2. doi: 10.1007/BF01981452.
3
Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines.两种新型催乳素释放抑制麦角灵的多巴胺激动活性
Eur J Pharmacol. 1984 Jun 1;101(3-4):263-6. doi: 10.1016/0014-2999(84)90167-5.
4
Pharmacodynamic profile of CQP 201-403, a novel 8 alpha-amino-ergoline.新型8α-氨基麦角灵CQP 201-403的药效学特征
Experientia. 1988 May 15;44(5):431-6. doi: 10.1007/BF01940539.
5
Biphasic influence of a 8 alpha-amino ergoline, CU 32-085, on striatal dopamine synthesis and turnover in vivo in the rat.一种8α-氨基麦角灵CU 32-085对大鼠体内纹状体多巴胺合成及周转的双相影响。
Life Sci. 1981 Nov 23;29(21):2227-34. doi: 10.1016/0024-3205(81)90494-x.
6
Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity.作为具有多巴胺能活性的部分麦角灵结构的取代5-氨基-4,5,6,7-四氢吲唑。
J Med Chem. 1989 Oct;32(10):2388-96. doi: 10.1021/jm00130a027.
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Interaction of sulfpride and ergot derivatives on rat brain DOPAC concentration and prolactin secretion in vivo.
Eur J Pharmacol. 1979 Jun;56(1-2):15-20. doi: 10.1016/0014-2999(79)90427-8.
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Life Sci. 1978 Dec 11;23(24):2383-91. doi: 10.1016/0024-3205(78)90296-5.
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Effect of ergoline derivative VUFB-6638 on the adenohypophysial prolactin concentration in rats.
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Changes in the concentration of adenohypophyseal prolactin and morphological manifestations in the adenohypophysis of lactating rats after administration of D-6-methyl-8-[beta-isopropylaminoethyl] ergoline-I.给予 D-6-甲基-8-[β-异丙基氨基乙基]麦角灵-I 后泌乳大鼠腺垂体催乳素浓度变化及腺垂体的形态学表现
Experientia. 1976 Oct 15;32(10):1308-9. doi: 10.1007/BF01953109.

引用本文的文献

1
Dopaminergic properties of mesulergine (CU 32-085) and its metabolites.美舒麦角（CU 32 - 085）及其代谢产物的多巴胺能特性。
J Neural Transm. 1984;60(3-4):225-38. doi: 10.1007/BF01249095.
2
Therapeutic experience with the new dopamine agonist CU 32-085 in advanced Parkinson's disease.
J Neurol. 1983;230(1):19-23. doi: 10.1007/BF00313593.
3
Mesulergine and bromocriptine in long-term treatment of advanced parkinsonism.美舒麦角和溴隐亭用于晚期帕金森病的长期治疗
J Neural Transm. 1985;64(1):45-54. doi: 10.1007/BF01259344.

本文引用的文献

1
Procedure for the simultaneous determination of dopamine, 3-methoxy-4-hydroxyphenylacetic acid, and 3,4-dihydroxyphenylacetic acid in brain.
Anal Biochem. 1971 Jul;42(1):113-8. doi: 10.1016/0003-2697(71)90016-9.
2
The interaction of the serotonergic and dopaminergic systems on prolactin secretion in the rat. The mechanism of action of the "specific" serotonin receptor antagonist, methysergide.血清素能系统与多巴胺能系统对大鼠催乳素分泌的相互作用。“特异性”血清素受体拮抗剂美西麦角的作用机制。
Endocrinology. 1978 Jul;103(1):287-95. doi: 10.1210/endo-103-1-287.
3
Prolactin secretion inhibition by a new 8alpha-amino-ergoline, CH 29-171.新型8α-氨基麦角灵CH 29-171对催乳素分泌的抑制作用
4
Three-year observation of mesulergine (CU 32-085) in advanced and newly treated parkinsonism.美舒麦角（CU 32 - 085）治疗晚期及初治帕金森病的三年观察
J Neurol. 1985;232(1):24-8. doi: 10.1007/BF00314036.
5
On the mode of action of six putative dopamine receptor agonists on suppression of exploratory behaviour in rats.六种假定的多巴胺受体激动剂对大鼠探究行为抑制作用的作用方式
Psychopharmacology (Berl). 1987;91(2):139-46. doi: 10.1007/BF00217053.
6
Mesulergine in early Parkinson's disease: a double blind controlled trial.美舒麦角治疗早期帕金森病：一项双盲对照试验。
J Neurol Neurosurg Psychiatry. 1986 Apr;49(4):390-5. doi: 10.1136/jnnp.49.4.390.
7
Pharmacodynamic profile of CQP 201-403, a novel 8 alpha-amino-ergoline.新型8α-氨基麦角灵CQP 201-403的药效学特征
Experientia. 1988 May 15;44(5):431-6. doi: 10.1007/BF01940539.
8
[3H]205-501, a non-catechol dopaminergic agonist, labels selectively and with high affinity dopamine D2 receptors.[3H]205 - 501，一种非儿茶酚胺多巴胺能激动剂，能选择性且高亲和力地标记多巴胺D2受体。
J Neural Transm. 1985;62(3-4):231-48. doi: 10.1007/BF01252239.
Experientia. 1978 Oct 15;34(10):1330-2. doi: 10.1007/BF01981452.
4
Neurochemical and neuropharmacological investigations with four ergot derivatives: bromocriptine, dihydroergotoxine, CF 25-397 and CM 29-712.四种麦角衍生物的神经化学和神经药理学研究：溴隐亭、双氢麦角毒碱、CF 25 - 397和CM 29 - 712。
Pharmacology. 1978;16 Suppl 1:156-73. doi: 10.1159/000136817.
5
Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas.多巴胺抑制人催乳素分泌型垂体腺瘤中的腺苷酸环化酶。
Nature. 1979 Mar 15;278(5701):252-4. doi: 10.1038/278252a0.