两种新型催乳素释放抑制性8α-氨基麦角灵。
Two novel prolactin release-inhibiting 8 alpha-amino-ergolines.
作者信息
Flückiger E, Briner U, Bürki H R, Marbach P, Wagner H R, Doepfner W
出版信息
Experientia. 1979 Dec 15;35(12):1677-8. doi: 10.1007/BF01953267.
PMID:520501
Abstract
Prolactin secretion inhibition and changes in striatal dopamine metabolism in rats were compared after the administration of 8 alpha-amino-ergoline CH 29-717 and 2 derivates. CQ 32-084 was similar to but less potent than CH 29-717, while 32-085, the l-methyl derivative, showed delayed dopaminomimetic effects.
摘要
在给予大鼠8α-氨基麦角灵CH 29-717及其2种衍生物后，比较了催乳素分泌抑制作用及纹状体多巴胺代谢的变化。CQ 32-084与CH 29-717相似，但效力较弱，而1-甲基衍生物32-085则表现出延迟的拟多巴胺效应。
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