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在白光和红光下进行的假松果体切除对大鼠松果体褪黑素含量的影响。

Effects of sham-pinealectomy, performed under white and red light, on the melatonin content of rat pineal glands.

作者信息

Frowein A, Lapin V

出版信息

Experientia. 1979 Dec 15;35(12):1681. doi: 10.1007/BF01953270.

DOI:10.1007/BF01953270
PMID:520503
Abstract

Sham-pinealectomy, performed under different light conditons in newborn and adult rats, is followed by changes of pineal activity resulting in variations of melatonin content. The pineal glands of rats sham-operated under white light produce significantly less melatonin. In contrast, glands of rats operated on under red light show a melatonin content corresponding to that of intact rats. This result implies that normal white light causes a disturbance in melatonin production by a non-retinal pathway.

摘要

在新生和成年大鼠的不同光照条件下进行假松果体切除术后,松果体活动会发生变化,导致褪黑素含量改变。在白光下进行假手术的大鼠松果体产生的褪黑素明显较少。相比之下,在红光下进行手术的大鼠松果体的褪黑素含量与完整大鼠的相当。这一结果表明,正常白光通过非视网膜途径干扰褪黑素的产生。

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本文引用的文献

1
Effect of light on the serotonin content of the pineal gland.光对松果体血清素含量的影响。
Life Sci I. 1971 Aug 15;10(16):955-60. doi: 10.1016/0024-3205(71)90360-2.
2
Action spectra for effects of light on hydroxyindole-o-methyl transferases in rat pineal, retina and harderian gland.光对大鼠松果体、视网膜和哈德氏腺中羟吲哚 - O - 甲基转移酶作用的作用光谱。
Endocrinology. 1972 Oct;91(4):877-86. doi: 10.1210/endo-91-4-877.
3
Fluorometric assay for 5-hydroxytryptophan with sensitivity in the picomole range.用于5-羟色氨酸的荧光测定法,灵敏度在皮摩尔范围内。
在红光或绿光下制备的绵羊松果体化合物对雄性大鼠垂体前叶体外活性的影响。
J Neural Transm. 1985;62(1-2):155-67. doi: 10.1007/BF01260424.
4
Effect of neonatal pinealectomy on circadian periodicity of adrenocortical activity.新生期松果体切除对肾上腺皮质活动昼夜节律的影响。
J Neural Transm. 1986;66(1):59-67. doi: 10.1007/BF01262958.
Anal Chem. 1975 Jan;47(1):7-11. doi: 10.1021/ac60351a004.
4
Effects of continuous light and darkness, and of pinealectomy, adrenalectomy and gonadectomy on uptake of 3H-serotonin by the suprachiasmatic nuclear region of male rats.持续光照与黑暗以及松果体切除、肾上腺切除和性腺切除对雄性大鼠视交叉上核区域摄取³H - 5 - 羟色胺的影响。
Neuroendocrinology. 1976;22(3):231-9. doi: 10.1159/000122630.
5
Effects of pinealectomy and of sham-pinealectomy on blood glucose levels in the alloxan-diabetic rat.松果体切除及假松果体切除对四氧嘧啶糖尿病大鼠血糖水平的影响。
Horm Metab Res. 1978 Sep;10(5):389-92. doi: 10.1055/s-0028-1093398.
6
A nonisotopic assay for acetylserotonin methyltransferase.一种用于测定乙酰血清素甲基转移酶的非同位素检测法。
Anal Biochem. 1978 Aug 1;88(2):580-6. doi: 10.1016/0003-2697(78)90459-1.
7
Neural control of pineal function in mammals and birds.哺乳动物和鸟类松果体功能的神经控制。
J Neural Transm Suppl. 1978(13):47-58.