含组织相容性抗原的脂蛋白诱导细胞介导的细胞毒性作用。
Induction of cell-mediated cytotoxicity by lipoprotein containing histocompatibility antigens.
作者信息
Dennert G
出版信息
Immunology. 1979 Dec;38(4):757-63.
Abstract
Lipoprotein was isolated from tumour cells by sonication and ultracentrifugal flotation on KBr gradients. It contained H-2 antigen detectable by antibody binding and induced a primary or secondary cell-mediated cytotoxic response in vitro which was H-2 specific. In a syngeneic model only a secondary cell-mediated response was stimulated and no competitive inhibition of the effector step of cell-mediated lysis could be demonstrated. The implications of these findings are discussed.
摘要
通过超声处理和在KBr梯度上进行超速离心浮选从肿瘤细胞中分离出脂蛋白。它含有可通过抗体结合检测到的H-2抗原，并在体外诱导了H-2特异性的初次或二次细胞介导的细胞毒性反应。在同基因模型中，仅刺激了二次细胞介导的反应，并且未证明对细胞介导的裂解效应步骤有竞争性抑制作用。讨论了这些发现的意义。
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Induction of cell-mediated cytotoxicity by lipoprotein containing histocompatibility antigens.含组织相容性抗原的脂蛋白诱导细胞介导的细胞毒性作用。
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本文引用的文献
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Inhibition of lymphocyte-mediated cytotoxicity (51Cr-release) by antisera preabsorbed with various cells.用各种细胞预先吸收的抗血清对淋巴细胞介导的细胞毒性（51Cr释放）的抑制作用。
J Natl Cancer Inst. 1974 Mar;52(3):769-75. doi: 10.1093/jnci/52.3.769.
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Blocking of syngeneic effector T cells by soluble tumour antigens.可溶性肿瘤抗原对同基因效应T细胞的阻断作用。
Nature. 1974 May 17;249(454):271-4. doi: 10.1038/249271a0.
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Cell-mediated cell lysis in vitro: genetic control of killer cell production and target specificities in the mouse.体外细胞介导的细胞裂解：小鼠中杀伤细胞产生和靶细胞特异性的遗传控制。
Eur J Immunol. 1974 May;4(5):378-87. doi: 10.1002/eji.1830040514.
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Cell-mediated lympholysis. Importance of serologically defined H-2 regions.细胞介导的淋巴细胞溶解。血清学定义的H-2区域的重要性。
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Effect of antigen density on complement-mediated lysis, T-cell-mediated killing, and antigenic modulation.抗原密度对补体介导的细胞裂解、T细胞介导的杀伤及抗原调变的影响。
J Natl Cancer Inst. 1974 Dec;53(6):1759-65.
7
T cell recognition of cell surface antigens. I. Specificity.T细胞对细胞表面抗原的识别。I. 特异性。
Eur J Immunol. 1974 Apr;4(4):240-6. doi: 10.1002/eji.1830040403.
8
Induction of the immune response to cell surface antigens in vitro.体外诱导对细胞表面抗原的免疫反应。
In Vitro. 1975 Jul-Aug;11(4):186-204. doi: 10.1007/BF02616334.
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Lymphocyte-mediated cytolysis of allogeneic tumor cells in vitro. I. Search for target antigens in subcellular fractions.淋巴细胞在体外对同种异体肿瘤细胞的介导细胞溶解作用。I. 亚细胞组分中靶抗原的寻找
Cell Immunol. 1975 Aug;18(2):304-23. doi: 10.1016/0008-8749(75)90059-3.
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