细胞介导的淋巴细胞溶解。血清学定义的H-2区域的重要性。
Cell-mediated lympholysis. Importance of serologically defined H-2 regions.
作者信息
Alter B J, Schendel D J, Bach M L, Bach F H, Klein J, Stimpfling J H
出版信息
J Exp Med. 1973 May 1;137(5):1303-9. doi: 10.1084/jem.137.5.1303.
Abstract
The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologically defined regions (H-2K and H-2D) are identical within each combination. H-2K or H-2D region disparity alone does not cause cell-mediated lympholysis. However after mixed lymphocyte culture activation as seen with B10.A-B10.T(6R), a target cell bearing only an H-2K region difference from the effector cell is sensitive to cell-mediated lympholysis. Likewise an H-2D region difference is an adequate target after mixed lymphocyte culture activation of the effector cell in the combination B10.A(2R)-B10.D2.
摘要
在混合淋巴细胞培养中受到刺激的小鼠脾细胞的细胞介导溶淋巴细胞能力与靶淋巴细胞上的主要组织相容性复合体基因型有关。导致显著混合淋巴细胞培养激活的品系组合AQR - B10.T(6R)和B10.A(4R) - B10.A(2R)不会介导对致敏靶淋巴细胞的细胞介导溶淋巴细胞作用；在每个组合中，血清学定义的区域（H - 2K和H - 2D）是相同的。单独的H - 2K或H - 2D区域差异不会引起细胞介导溶淋巴细胞作用。然而，如在B10.A - B10.T(6R)中所见，在混合淋巴细胞培养激活后，仅与效应细胞存在H - 2K区域差异的靶细胞对细胞介导溶淋巴细胞作用敏感。同样，在组合B10.A(2R) - B10.D2中效应细胞经混合淋巴细胞培养激活后，H - 2D区域差异足以成为靶标。
相似文献
1
Cell-mediated lympholysis. Importance of serologically defined H-2 regions.细胞介导的淋巴细胞溶解。血清学定义的H-2区域的重要性。
J Exp Med. 1973 May 1;137(5):1303-9. doi: 10.1084/jem.137.5.1303.
2
Mixed lymphocyte reactivity and cell-mediated lympholysis to D-end differences of the murine major histocompatibility complex. Comparison of in vitro responses to exclusive D-end or more extensive MHC differences.针对小鼠主要组织相容性复合体D端差异的混合淋巴细胞反应和细胞介导的淋巴细胞溶解。对仅D端差异或更广泛的主要组织相容性复合体差异的体外反应比较。
Scand J Immunol. 1976;5(4):369-82. doi: 10.1111/j.1365-3083.1976.tb00291.x.
3
Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex.三硝基苯基修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。效应细胞对由小鼠主要组织相容性复合体的H-2K和H-2D血清学区域控制的修饰细胞表面成分的特异性。
J Exp Med. 1975 Jun 1;141(6):1348-64. doi: 10.1084/jem.141.6.1348.
4
Cell-mediated lympholysis of N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-beta-anaylglycylglycyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by the H-2K and H-2D serological regions of the murine major histocompatibility complex.N-（3-硝基-4-羟基-5-碘苯乙酰基）-β-丙氨酰甘氨酰修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。效应细胞对由小鼠主要组织相容性复合体的H-2K和H-2D血清学区域控制的修饰细胞表面成分的特异性。
J Exp Med. 1976 Jan 1;143(1):127-42. doi: 10.1084/jem.143.1.127.
5
Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.H-2 D相关的T细胞介导的对三硝基苯基修饰的自体细胞的淋巴细胞溶解的多个H-2连锁免疫反应基因控制：定位于I-A左侧和I区内的类Ir基因。
J Exp Med. 1976 Dec 1;144(6):1701-6. doi: 10.1084/jem.144.6.1701.
6
Cell-mediated immunity: differential maturation of mixed leukocyte reaction and cell-mediated lympholysis.细胞介导的免疫：混合淋巴细胞反应和细胞介导的淋巴细胞溶解的差异成熟
J Exp Med. 1975 Nov 1;142(5):1301-5. doi: 10.1084/jem.142.5.1301.
7
8
Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.三硝基苯基修饰的自体淋巴细胞的细胞介导淋巴细胞溶解。通过使用抗H-2和抗Ia抗体证实对三硝基苯基修饰的H-2抗原反应的遗传控制。
J Exp Med. 1976 Jan 1;143(1):211-7. doi: 10.1084/jem.143.1.211.
9
Alloantigen-activated lysis of syngenic tumor augmented by allogenic lymphocytes as cold targets.
Oncology. 1985;42(6):377-83. doi: 10.1159/000226067.
10
H-2-linked genetic control of murine T-cell-mediated lympholysis to autologous cells modified with low concentrations of trinitrobenzene sulfonate.H-2相关的小鼠T细胞介导的对用低浓度三硝基苯磺酸修饰的自体细胞的淋巴细胞溶解的遗传控制。
J Exp Med. 1979 Jun 1;149(6):1407-23. doi: 10.1084/jem.149.6.1407.
引用本文的文献
1
Involvement of CD4(+) Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma cruzi.CD4(+) Th1细胞参与针对克氏锥虫初次和再次攻击的全身免疫保护。
Infect Immun. 2000 Jan;68(1):197-204. doi: 10.1128/IAI.68.1.197-204.2000.
2
Immune response to acute virus infection in the Syrian hamster. I. Studies on genetic restriction of cell-mediated cytotoxicity.叙利亚仓鼠对急性病毒感染的免疫反应。I. 细胞介导的细胞毒性的遗传限制研究。
Immunogenetics. 1980;10(2):185-99. doi: 10.1007/BF01561567.
3
Variation of expression of histocompatibility antigens on tumor cells: absence of H-2Kk-gene products from a gross-virus-induced leukemia in BALB.K.肿瘤细胞上组织相容性抗原表达的变化：BALB.K品系中一种粗病毒诱导的白血病缺乏H-2Kk基因产物
Immunogenetics. 1981;14(3-4):323-39. doi: 10.1007/BF00342201.
4
Assessment of environmental contaminant-induced lymphocyte dysfunction.环境污染物诱导的淋巴细胞功能障碍评估。
Environ Health Perspect. 1981 Jun;39:105-28. doi: 10.1289/ehp.8139105.
5
Recognition of polymorphic H-2 domains by T lymphocytes. I. Functional role of different H-2 domains for the generation of alloreactive cytotoxic T lymphocytes and determination of precursor frequencies.T淋巴细胞对多态性H-2结构域的识别。I. 不同H-2结构域在同种异体反应性细胞毒性T淋巴细胞生成中的功能作用及前体细胞频率的测定。
J Exp Med. 1981 Dec 1;154(6):1717-31. doi: 10.1084/jem.154.6.1717.
6
Use of H-2 mutations to quantitate alloreactivity: Alloreactivity is strongest against H-2 antigens which are closet to self.利用H-2突变来定量同种异体反应性：同种异体反应性对与自身最接近的H-2抗原最强。
Immunogenetics. 1980;11(2):111-21. doi: 10.1007/BF01567777.
7
Alloreactive T-cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products.同种反应性T细胞克隆。Ly表型可预测对主要组织相容性复合体产物的功能和特异性。
Immunogenetics. 1983;17(2):147-65. doi: 10.1007/BF00364755.
8
Allospecific and virus-specific cytolytic T lymphocytes are restricted to the N or C1 domain of H-2 antigens expressed on L cells after DNA-mediated gene transfer.同种特异性和病毒特异性细胞溶解T淋巴细胞受限于DNA介导的基因转移后在L细胞上表达的H-2抗原的N或C1结构域。
Proc Natl Acad Sci U S A. 1983 May;80(9):2709-12. doi: 10.1073/pnas.80.9.2709.
9
Pancreatic islet transplantation. Induction of graft acceptance by ultraviolet irradiation of donor tissue.胰岛移植。通过对供体组织进行紫外线照射诱导移植耐受。
Ann Surg. 1984 Oct;200(4):441-50. doi: 10.1097/00000658-198410000-00005.
10
Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains.通过分离前两个外部结构域的重组H-2基因剖析小鼠主要组织相容性抗原上的血清学和细胞溶解性T淋巴细胞表位
J Exp Med. 1984 Jul 1;160(1):167-78. doi: 10.1084/jem.160.1.167.
本文引用的文献
1
Spleen cell proliferation in response to homologous antigens studied in congenic resistant strains of mice.在同基因抗性小鼠品系中研究的对同源抗原作出反应的脾细胞增殖。
J Exp Med. 1966 Apr 1;123(4):665-71. doi: 10.1084/jem.123.4.665.
2
Phenotypic expressions of the major histocompatibility locus in man (HL-A): leukocyte antigens and mixed leukocyte culture reactivity.人类主要组织相容性位点（HL-A）的表型表达：白细胞抗原与混合白细胞培养反应性。
J Exp Med. 1968 Oct 1;128(4):623-37. doi: 10.1084/jem.128.4.623.
3
Mixed lymphocyte culture and HL-A.混合淋巴细胞培养与组织相容性抗原A
Transplant Proc. 1972 Jun;4(2):199-204.
4
Allogeneic and xenogeneic response in mixed leukocyte cultures.混合白细胞培养中的同种异体和异种反应。
J Exp Med. 1972 May 1;135(5):1204-8. doi: 10.1084/jem.135.5.1204.
5
A sex-limited serum protein variant in the mouse: inheritance and association with the H-2 region.小鼠中的一种性别限制血清蛋白变体：遗传及与H-2区域的关联。
Biochem Genet. 1970 Jun;4(3):351-65. doi: 10.1007/BF00485752.
6
Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.小鼠主要组织相容性复合体的血清学定义成分和淋巴细胞定义成分。
J Exp Med. 1972 Dec 1;136(6):1430-44. doi: 10.1084/jem.136.6.1430.
7
Three closely linked genetic systems relevant to transplantation.与移植相关的三个紧密相连的遗传系统。
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3031-5. doi: 10.1073/pnas.68.12.3031.
8
Histocompatibility-linked immune response genes.组织相容性连锁免疫反应基因
Science. 1972 Jan 21;175(4019):273-9. doi: 10.1126/science.175.4019.273.
9
The H-2 model for the major histocompatibility systems.主要组织相容性系统的H-2模型。
Transplant Rev. 1971;6:3-29. doi: 10.1111/j.1600-065x.1971.tb00457.x.
Zotero 插件