健康受试者和住院患者中的抗球蛋白试验假阳性
False-positive antiglobulin tests in healthy subjects and in hospital patients.
作者信息
Freedman J
出版信息
J Clin Pathol. 1979 Oct;32(10):1014-8. doi: 10.1136/jcp.32.10.1014.
Abstract
An antiglobulin reagent containing anti-IgG, -C4c, -C4d, -C3c, and -C3d was used to test red blood cells from healthy subjects and from patients in hospital. In tests read macroscopically on opal tiles, no positive reactions were found in the healthy subjects. Positive reactions were, however, observed in 7% of the hospital patients. Further tests with monospecific reagents showed the positive reactions to be due to the presence of C4d and C3d on the red cells. All patients with positive antiglobulin reactions had serious disease, in most cases associated with abnormal antibody production or abnormal immunoglobulin levels.
摘要
一种含有抗IgG、抗C4c、抗C4d、抗C3c和抗C3d的抗球蛋白试剂被用于检测健康受试者和住院患者的红细胞。在乳白瓷砖上进行宏观读数的检测中，健康受试者未发现阳性反应。然而，在7%的住院患者中观察到了阳性反应。用单特异性试剂进行的进一步检测表明，阳性反应是由于红细胞上存在C4d和C3d。所有抗球蛋白反应阳性的患者都患有严重疾病，大多数情况下与异常抗体产生或异常免疫球蛋白水平有关。
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本文引用的文献
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