Webb A K, Mitchell D N, Bradstreet C M, Salsbury A J
J Clin Pathol. 1979 Oct;32(10):1050-3. doi: 10.1136/jcp.32.10.1050.
The natural history of 30 patients with sarcoidosis who showed histological evidence of granulomatous involvement of the spleen has been studied; 24 patients had splenomegaly, 16 of whom had splenectomy. The main indication for splenectomy was splenomegaly and resultant discomfort. Corticosteroids reduced spleen size but reduction or withdrawal of the relatively high dosage required resulted in rebound splenomegaly within a period of three months to three years. Haematological abnormalities were controlled by splenectomy in all patients so affected, but the natural history of their sarcoidosis remained unaltered.
对30例有脾脏肉芽肿性病变组织学证据的结节病患者的自然病史进行了研究；24例患者有脾肿大，其中16例行脾切除术。脾切除术的主要指征是脾肿大及由此引起的不适。皮质类固醇可使脾脏缩小，但在减少或停用所需的相对高剂量后，在3个月至3年的时间内会出现脾脏肿大反弹。脾切除术可控制所有有血液学异常的患者的病情，但他们结节病的自然病史并未改变。
