植物抗癌剂。IX. 绒毛香科叶草的成分。

Plant anticancer agents. IX. Constituents of Hyptis tomentosa.

作者信息

Kingston D G, Rao M M, Zucker W V

出版信息

J Nat Prod. 1979 Sep-Oct;42(5):496-9. doi: 10.1021/np50005a010.

Abstract

The twigs, leaves, and flowers of Hyptis tomentosa were found to owe their major cytotoxic activity to the presence of desoxypodophyllotoxin (4), but the two weakly cytotoxic flavones 5-hydroxy-4',6,7,8-tetramethoxy flavone (3) and 5-hydroxy-4',3,6,7,8-pentamethoxy flavone (2) also contributed to the total cytotoxicity of the crude extracts. The flavones eupatorin (6) and 5-hydroxy-3',4',6,7-tetramethoxy flavone (5) were isolated as inactive constituents, together with the lignan sesamin (1).

摘要

绒毛香科叶草的嫩枝、叶子和花朵被发现，其主要细胞毒性活性归因于脱氧鬼臼毒素（4）的存在，但两种细胞毒性较弱的黄酮类化合物5-羟基-4',6,7,8-四甲氧基黄酮（3）和5-羟基-4',3,6,7,8-五甲氧基黄酮（2）也对粗提物的总细胞毒性有贡献。黄酮类化合物泽兰苦内酯（6）和5-羟基-3',4',6,7-四甲氧基黄酮（5）与木脂素芝麻素（1）一起被分离为无活性成分。