Da Pian R, Pasqualin A, Scienza R, Vivenza C, Malesani G C
J Neurosurg Sci. 1979 Apr-Jun;23(2):109-20.
The authors report 73 cases of intracranial arterial aneurysms operated on under deep controlled hypotension--i.e. hypotension below 60 mmHg of systolic arterial pressure (s.a.p.)--. Deep hypotension was induced by Sodium Nitroprusside (SNP). No problems were encountered in order to reach or to maintain deep hypotension. SNP showed to be an easy hypotensive agent, without toxicity at the recommended dosage. Fifty-nine patients were operated on between 40 and 25 mmHg of s.a.p. In 55 patients deep hypotension lasted for 30 minutes or more, reaching 2 hours in 3 patients. Surgical results were excellent, in regard either to the control of bleeding, either to the dissection of the aneurysm. Clinical results were evaluated by comparison with 146 patients operated on under normal pressure (group of control); no complications were clearly related to deep hypotension per se. However, the authors stress the risks of deep hypotension in early surgery, due to the possible association to vascular spasm.
作者报告了73例在深度控制性低血压（即收缩动脉压低于60 mmHg）下进行手术的颅内动脉瘤病例。深度低血压由硝普钠（SNP）诱导。在达到或维持深度低血压方面未遇到问题。SNP被证明是一种易于使用的降压药物，在推荐剂量下无毒性。59例患者在收缩动脉压40至25 mmHg之间进行了手术。55例患者深度低血压持续30分钟或更长时间，3例患者达到2小时。无论是在控制出血还是在动脉瘤解剖方面，手术结果都非常出色。通过与146例在正常血压下进行手术的患者（对照组）进行比较来评估临床结果；没有并发症明显与深度低血压本身相关。然而，作者强调早期手术中深度低血压的风险，因为可能与血管痉挛有关。
