Klemm W R, Engen R L
J Neurosci Res. 1979;4(5-6):371-82. doi: 10.1002/jnr.490040506.
As a follow-up to a previous study that suggested that acutely administered ethanol could decrease steady-state brain levels of sialic acid (SA), we evaluated the time course of the ethanol effect and tested the influence of route of administration and sex. Compared to the control treatments, ethanol (2 gm/kg) significantly decreased brain SA in each of the four brain regions that were tested. The decrease was evident by 30 minutes after ethanol administration, but peak effect was reached at about 1--2 hours. The decrease occurred with either injection or self-administration, but the greatest decrease occurred in the self-administration group. The SA-induced decrease was greatest in females. An ancillary part of the study included measurement of brain levels of 2-deoxyribose (DR). Ethanol given by either route of administration caused a preferential decrease in DR levels in the cerebellum. Lesser, but statistically significant, decreases in SA and DR occurred in controls, suggesting that these chemicals are sensitive to subtle environmental contingencies associated with the experimental procedures.
作为之前一项研究的后续，该研究表明急性给予乙醇可降低稳态脑唾液酸（SA）水平，我们评估了乙醇作用的时间进程，并测试了给药途径和性别的影响。与对照处理相比，乙醇（2克/千克）显著降低了所测试的四个脑区中的每一个脑区的脑SA水平。乙醇给药后30分钟下降明显，但在约1-2小时达到最大效应。无论是注射还是自我给药都会出现下降，但自我给药组下降最大。SA诱导的下降在女性中最大。该研究的一个辅助部分包括测量脑2-脱氧核糖（DR）水平。通过任何一种给药途径给予的乙醇都会导致小脑DR水平优先下降。对照组中SA和DR的下降较小但具有统计学意义，这表明这些化学物质对与实验程序相关的细微环境意外情况敏感。
