Calabrese E J
Med Hypotheses. 1979 Sep;5(9):995-7. doi: 10.1016/0306-9877(79)90047-1.
Individuals who have a reduced capacity to detoxify cyanide to thiocyanate are at increased risk to experience adverse side effects from laetrile, a cyanide containing substance used in cancer treatment. Since megadoses of ascorbic acid may markedly diminish body stores of cysteine, a sulfur containing amino acid which facilitates the detoxification of cyanide, it is predicted that persons consuming megadoses of ascorbic acid will be at increased risk to experience the adverse side effects from laetrile treatment.
将氰化物解毒为硫氰酸盐能力降低的个体，在接受苦杏仁苷（一种用于癌症治疗的含氰化物物质）治疗时，出现不良副作用的风险会增加。由于大剂量的抗坏血酸可能会显著减少半胱氨酸（一种促进氰化物解毒的含硫氨基酸）的体内储备，因此预计摄入大剂量抗坏血酸的人在接受苦杏仁苷治疗时出现不良副作用的风险会增加。
