Calabrese E J
Med Hypotheses. 1979 Sep;5(9):1045-9. doi: 10.1016/0306-9877(79)90053-7.
Individuals who have a diminished capacity to detoxify cyanide to thiocyanate because of either a genetic predisposition (e.g. as occurs in those with Leber's Optic Atrophy) or a diet low in sulfur containing amino acids are predicted to be at increased risk to developing adverse side effects from laetrile, a cyanide containing substance used in cancer treatment.
由于遗传易感性（例如在患有莱伯氏视神经萎缩症的人群中出现）或含硫氨基酸含量低的饮食，导致将氰化物解毒为硫氰酸盐的能力减弱的个体，预计会因苦杏仁苷（一种用于癌症治疗的含氰化物物质）产生不良副作用的风险增加。
