Quinn J J, Taylor C R, Swanson V, Williams A H, Schneider B K, Higgins G R, Tindle B H, Powars D, Lincoln T, Chandor S B, Pattenagle P, Siegel S E, Lukes R J
Med Pediatr Oncol. 1979;7(1):35-47. doi: 10.1002/mpo.2950070107.
Malignant cells from 49 children with lymphoid neoplasms other than Hodgkin disease were evaluated by surface marker and morphologic studies. We classified the patients into three groups: 36 patients (74%) with acute lymphocytic leukemia; 7 (14%) classified as convoluted lymphocytic lymphoma/leukemia; and 6 (12%) with small noncleaved follicular center cell lymphoma/leukemia. Diffuse marrow involvement was present at diagnosis in some patients in the latter two groups, but their clinical course was not characteristic of the patients with acute lymphocytic leukemia. Male predominance, poor prognosis, and high incidence of central nervous system disease characterized patients in the convoluted lymphocytic and follicular center cell lymphoma/leukemia groups. Clinical presentation in these two groups differed. Proliferations of convoluted lymphocytes were associated with mediastinal masses and proliferations of follicular center cells with intraabdominal tumors. The high incidence of CNS disease in children with neoplasms of convoluted lymphocytes and follicular center cells suggests that these processes have a predilection for the CNS and that patients with them may benefit from CNS prophylaxis.
对49例非霍奇金病的淋巴样肿瘤患儿的恶性细胞进行了表面标志物和形态学研究。我们将患者分为三组：36例（74%）急性淋巴细胞白血病患者；7例（14%）归为卷曲淋巴细胞淋巴瘤/白血病；6例（12%）为小无裂滤泡中心细胞淋巴瘤/白血病。后两组中的一些患者在诊断时存在弥漫性骨髓受累，但其临床病程并非急性淋巴细胞白血病患者的典型病程。卷曲淋巴细胞和滤泡中心细胞淋巴瘤/白血病组患者的特征为男性居多、预后不良及中枢神经系统疾病发生率高。这两组的临床表现有所不同。卷曲淋巴细胞增殖与纵隔肿块有关，而滤泡中心细胞增殖与腹内肿瘤有关。卷曲淋巴细胞和滤泡中心细胞肿瘤患儿中枢神经系统疾病的高发生率表明，这些病变易累及中枢神经系统，患有这些疾病的患者可能会从中枢神经系统预防措施中获益。
