Boucheix C, Diebold J, Bernadou A, Reynes M, Tulliez M, Cadiou M, Paczynski V, Capron F, Bilski-Pasquier G
Cancer. 1980 Apr 1;45(7):1569-77. doi: 10.1002/1097-0142(19800401)45:7<1569::aid-cncr2820450710>3.0.co;2-l.
This work is devoted to the analysis of the nature of lymphoblastic lymphoma/leukemia with convoluted nuclei which were initially described by Barcos and Lukes. Ultrastructural, cytochemical, and immunologic features of tumor cells were investigated in patients chosen according to known morphologic criteria. Through results of the E rosette test, the patients were divided into two groups (E+ and E-). In the E+ group, the predominant features were sex (only men), the mediastinal localization, and the focal positivity of the acid phosphatase reaction. Cytotoxicity tests with rabbit antihuman T-lymphocyte anti-serum confirmed the results of the E rosette test in the 3 patients of the E+ group who were tested and were also positive in 2 patients from the E- group (1 of these 2 patients had the characteristics found in the E+ group and can thus be related to this group; the other patient had none of these characteristics). This raises the question of a leukemia arising from a less differentiated T-cell but this interpretation is limited by the specificity of the anti-T-serum. Ultrastructural study defines more precisely the convoluted aspect but does not at present allow a distinction between the two groups.
这项工作致力于分析最初由巴科斯和卢克斯描述的具有卷曲核的淋巴母细胞淋巴瘤/白血病的本质。根据已知的形态学标准选择患者，对肿瘤细胞的超微结构、细胞化学和免疫学特征进行了研究。通过E玫瑰花结试验的结果，将患者分为两组（E+和E-）。在E+组中，主要特征为性别（仅男性）、纵隔定位以及酸性磷酸酶反应的局灶性阳性。用兔抗人T淋巴细胞抗血清进行的细胞毒性试验证实了E玫瑰花结试验在接受检测的3例E+组患者中的结果，并且在E-组的2例患者中也呈阳性（这2例患者中的1例具有E+组中发现的特征，因此可与该组相关；另1例患者没有这些特征）。这就提出了一种由分化程度较低的T细胞引起的白血病的问题，但这种解释受到抗T血清特异性的限制。超微结构研究更精确地界定了卷曲形态，但目前无法区分这两组。
