造影剂在大鼠体内外组胺的释放情况
In vitro and in vivo release of histamine by contrast media in the rat.
作者信息
Leite M P, de Moraes C R, Leme J G
出版信息
Acta Radiol Diagn (Stockh). 1975 Mar;16(2):172-80. doi: 10.1177/028418517501600208.
PMID:52284
Abstract
Some contrast media are able to release histamine from isolated mast cells of the rat and produce degranulation of these cells. Such properties are fairly correlated with the ability to increase vascular permeability in vivo and to produce a drop in blood pressure. If histamine is similarly being released in humans many untoward effects of these agents referred to clinically might be thus explained.
摘要
一些造影剂能够从大鼠分离的肥大细胞中释放组胺，并使这些细胞脱颗粒。这些特性与体内增加血管通透性和导致血压下降的能力密切相关。如果组胺在人体内也以类似方式释放，那么临床上提到的这些药物的许多不良反应或许就能得到解释。
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