小鼠颌下唾液腺7S神经生长因子诱导的组胺释放

Histamine-release induced by 7S nerve-growth factor of mouse submandibular salivary glands.

作者信息

Sugiyama K, Suzuki Y, Furuta H

出版信息

Arch Oral Biol. 1985;30(1):93-5. doi: 10.1016/0003-9969(85)90031-7.

Abstract

The 7S nerve-growth factor (7S NGF) purified from mouse submandibular glands induced histamine release from rat-isolated mast cells in the presence of lysophosphatidyl-serine. When 7S NGF was injected intradermally into the rat skin, the vascular permeability increased. This response was abolished by the antihistamine, diphenhydramine. These results show that 7S NGF acts as a potent histamine releaser.

摘要

从小鼠颌下腺纯化得到的7S神经生长因子（7S NGF）在溶血磷脂酰丝氨酸存在的情况下，可诱导大鼠分离的肥大细胞释放组胺。当将7S NGF皮内注射到大鼠皮肤中时，血管通透性增加。这种反应可被抗组胺药苯海拉明消除。这些结果表明，7S NGF是一种有效的组胺释放剂。