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Multiple forms of fructose diphosphate aldolase in mammalian tissues.

作者信息

Penhoet E, Rajkumar T, Rutter W J

出版信息

Proc Natl Acad Sci U S A. 1966 Oct;56(4):1275-82. doi: 10.1073/pnas.56.4.1275.

DOI:10.1073/pnas.56.4.1275
PMID:5230152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC220058/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/696cbc04f710/pnas00165-0223-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/b775d0b00e65/pnas00165-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/e6cb002a963c/pnas00165-0221-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/543607762dba/pnas00165-0223-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/696cbc04f710/pnas00165-0223-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/b775d0b00e65/pnas00165-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/e6cb002a963c/pnas00165-0221-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/543607762dba/pnas00165-0223-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/220058/696cbc04f710/pnas00165-0223-b.jpg

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1
Multiple forms of fructose diphosphate aldolase in mammalian tissues.哺乳动物组织中果糖二磷酸醛缩酶的多种形式。
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1275-82. doi: 10.1073/pnas.56.4.1275.
2
[Isoenzyme fractions of fructosephosphate aldolase in human organs during embryonic development. Isoenzymes of fructosephosphate aldolase. VII].胚胎发育过程中人体器官中磷酸果糖醛缩酶的同工酶组分。磷酸果糖醛缩酶的同工酶。VII
Z Klin Chem Klin Biochem. 1969 Nov;7(6):601-5.
3
Distribution of fructose diphosphate aldolase variants in biological systems.果糖二磷酸醛缩酶变体在生物系统中的分布。
Biochemistry. 1969 Jan;8(1):109-21. doi: 10.1021/bi00829a016.
4
On the ubiquity of aldolase C in ruminant tissues.关于醛缩酶C在反刍动物组织中的普遍存在
Biochim Biophys Acta. 1969 May 27;178(3):623-5. doi: 10.1016/0005-2744(69)90231-9.
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[Changes in the isoenzyme patterns of aldolases from rat organs during development].[大鼠器官中醛缩酶同工酶谱在发育过程中的变化]
Hoppe Seylers Z Physiol Chem. 1967 Jul;348(7):921-8.
6
[Further studies on the isoenzyme patterns of fructosephosphate aldolase in human organs. Isoenzyme of fructosephosphate aldolase. VI].[人器官中磷酸果糖醛缩酶同工酶模式的进一步研究。磷酸果糖醛缩酶同工酶。VI]
Z Klin Chem Klin Biochem. 1969 May;7(3):278-81.
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Ioslation of fructose diphosphate aldolases A, B, and C.果糖二磷酸醛缩酶A、B和C的分离
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Detection and isolation of mammalian fructose-diphosphate aldolases.哺乳动物果糖二磷酸醛缩酶的检测与分离
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Molecular and catalytic properties of aldolase C.醛缩酶C的分子与催化特性
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10
Phosphorylase isoenzymes in tissues: prevalence of the liver type in man.组织中的磷酸化酶同工酶：人类肝脏型的普遍性
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ALDOB is a prognostic biomarker and a potential immunotherapy target for clear cell renal cell carcinoma.醛缩酶B（ALDOB）是透明细胞肾细胞癌的一种预后生物标志物和潜在的免疫治疗靶点。
PeerJ. 2025 Aug 18;13:e19869. doi: 10.7717/peerj.19869. eCollection 2025.
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Do microglia metabolize fructose in Alzheimer's disease?在阿尔茨海默病中，小胶质细胞会代谢果糖吗？
J Neuroinflammation. 2025 Mar 15;22(1):85. doi: 10.1186/s12974-025-03401-x.
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ALDOA contributes to colorectal tumorigenesis and metastasis by targeting YAP.醛缩酶A通过靶向Yes相关蛋白（YAP）促进结直肠癌的发生和转移。

本文引用的文献

1
STUDIES ON THE CARBOXYL- AND AMINO-TERMINAL RESIDUES OF RABBIT MUSCLE ALDOLASE.兔肌肉醛缩酶羧基末端和氨基末端残基的研究
J Biol Chem. 1964 Dec;239:4212-6.
2
EVOLUTION OF ALDOLASE.醛缩酶的进化
Fed Proc. 1964 Nov-Dec;23:1248-57.
3
COMPARATIVE STUDIES OF LIVER AND MUSCLE ALDOLASE. II. IMMUNOCHEMICAL AND CHROMATOGRAPHIC DIFFERENTIATION.肝脏和肌肉醛缩酶的比较研究。II. 免疫化学和色谱鉴别
Cell Death Discov. 2025 Jan 5;10(1):489. doi: 10.1038/s41420-024-02249-z.
4
Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1.热蛋白质组谱分析揭示 1,6-二磷酸果糖可作为磷酸供体激活磷酸甘油酸变位酶 1。
Nat Commun. 2024 Oct 16;15(1):8936. doi: 10.1038/s41467-024-53238-w.
5
ALDOB plays a tumor-suppressive role by inhibiting AKT activation in gastric cancer.醛缩酶B（ALDOB）通过抑制胃癌中AKT的激活发挥肿瘤抑制作用。
J Cancer. 2023 Jul 16;14(12):2255-2262. doi: 10.7150/jca.83456. eCollection 2023.
6
Bioinformatics identification of prognostic genes and potential interaction analysis in renal cell carcinoma.肾细胞癌预后基因的生物信息学鉴定及潜在相互作用分析
Transl Cancer Res. 2023 Apr 28;12(4):774-783. doi: 10.21037/tcr-22-2242. Epub 2023 Mar 29.
7
The testis-, epididymis-, or seminal vesicle-enriched genes Aldoart2, Serpina16, Aoc1l3, and Pate14 are not essential for male fertility in mice.睾丸、附睾或精囊丰富基因 Aldoart2、Serpina16、Aoc1l3 和 Pate14 对于小鼠的雄性生育力并非必需。
Exp Anim. 2023 Aug 7;72(3):314-323. doi: 10.1538/expanim.22-0158. Epub 2023 Jan 30.
8
Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.醛缩酶B通过抑制葡萄糖-6-磷酸脱氢酶（G6PD）和磷酸戊糖途径来抑制肝细胞癌发生。
Nat Cancer. 2020 Jul;1(7):735-747. doi: 10.1038/s43018-020-0086-7. Epub 2020 Jul 6.
9
Interrogating the Role of the Two Distinct Fructose-Bisphosphate Aldolases of by Site-Directed Mutagenesis of Key Amino Acids and Gene Repression by CRISPR Interference.通过关键氨基酸的定点诱变和CRISPR干扰介导的基因抑制来探究两种不同的果糖-1,6-二磷酸醛缩酶的作用。
Front Microbiol. 2021 Apr 30;12:669220. doi: 10.3389/fmicb.2021.669220. eCollection 2021.
10
Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease.遗传性果糖不耐受发病机制的最新进展：对其治疗和果糖诱导的非酒精性脂肪性肝病认识的影响。
Cell Mol Life Sci. 2020 May;77(9):1709-1719. doi: 10.1007/s00018-019-03348-2. Epub 2019 Nov 12.
J Biol Chem. 1963 Oct;238:3280-5.
4
Reversible dissociation of aldolase into unfolded subunits.
Biochemistry. 1963 Mar-Apr;2:246-51. doi: 10.1021/bi00902a007.
5
The dissociation and reconstitution of aldolase.醛缩酶的解离与重组。
Biochemistry. 1962 Nov;1:1056-69. doi: 10.1021/bi00912a016.
6
The catalytic activity of carboxypeptidase-degraded aldolase.羧肽酶降解醛缩酶的催化活性。
J Biol Chem. 1959 Oct;234:2627-34.
7
The number of polypeptide chains in rabbit muscle aldolase.兔肌肉醛缩酶中的多肽链数量。
Biochemistry. 1966 May;5(5):1578-84. doi: 10.1021/bi00869a018.
8
The binding-sites of rabbit muscle aldolase.
Biochem Biophys Res Commun. 1966 Apr 19;23(2):182-7. doi: 10.1016/0006-291x(66)90525-0.