Quismorio F P, Bjarnason D F, Kiely W F, Dubois E L, Friou G J
Am J Psychiatry. 1975 Nov;132(11):1204-6. doi: 10.1176/ajp.132.11.1204.
The authors found a significantly higher incidence of antinuclear antibodies (ANA) and positive lupus erythematosus cell tests in chronic psychotic patients who received 400 mg a day or more of chlorpromazine (CPZ) for at least 7 weeks than in those who had taken 50 to 300 mg a day for varying periods or those who had received no CPZ for at least 3 months. Despite the high incidence of ANA, there was no observed development of lupuslike syndrome. The authors suggest that CPZ in high doses may induce ANA in humans.
作者发现，与那些在不同时间段每天服用50至300毫克氯丙嗪（CPZ）的患者或至少3个月未服用CPZ的患者相比，每天服用400毫克或更多CPZ至少7周的慢性精神病患者中，抗核抗体（ANA）的发生率和狼疮细胞试验阳性率显著更高。尽管ANA发生率很高，但未观察到类似狼疮综合征的发展。作者认为，高剂量的CPZ可能会在人体内诱导ANA产生。
