Zarrabi M H, Zucker S, Miller F, Derman R M, Romano G S, Hartnett J A, Varma A O
Ann Intern Med. 1979 Aug;91(2):194-9. doi: 10.7326/0003-4819-91-2-194.
The prevalence of immunologic and coagulation disorders in 75 schizophrenic patients treated with chlorpromazine or other antipsychotic drugs was evaluated. Four groups were studied: Group A, chlorpromazine treatment for more than 2 1/2 years; Group B, chlorpromazine and other antipsychotic drug treatment for more than 2 1/2 years; Group C, chlorpromazine treatment for less than 2 1/2 years; Group D, no chlorpromazine, but other antipsychotic drug treatment. Significant elevation of serum IgM and prolongation of partial thromboplastin time were noted in patients who had long-term chlorpromazine treatment. The latter was caused by a circulating inhibitor resembling that seen with systemic lupus erythematosus. There was a significant correlation between the IgM level versus chlorpromazine dose or duration of treatment and the partial thromboplastin time versus chlorpromazine dose or duration of treatment. In Groups A and B, 63% had a positive antinuclear antibody test (greater than or equal to 1:80), 40% had antibodies to native DNA, and 58% had antibodies to nucleoprotein. These antibodies were negative in the other groups. The percentages of T lymphocytes were below normal in 13 of 41 patients treated with chlopromazine. Twenty of 42 patients in Groups A and B, and none of 28 in Groups C and D had splenomegaly. This study indicates that most patients on long-term chlorpromazine treatment develop one or more immunologic abnormalities.
对75例接受氯丙嗪或其他抗精神病药物治疗的精神分裂症患者的免疫和凝血障碍患病率进行了评估。研究了四组：A组，氯丙嗪治疗超过2.5年；B组，氯丙嗪和其他抗精神病药物治疗超过2.5年；C组，氯丙嗪治疗少于2.5年；D组，未用氯丙嗪，但接受其他抗精神病药物治疗。长期接受氯丙嗪治疗的患者血清IgM显著升高，部分凝血活酶时间延长。后者是由一种类似于系统性红斑狼疮所见的循环抑制剂引起的。IgM水平与氯丙嗪剂量或治疗持续时间以及部分凝血活酶时间与氯丙嗪剂量或治疗持续时间之间存在显著相关性。在A组和B组中，63%的患者抗核抗体试验呈阳性（大于或等于1:80），40%的患者有抗天然DNA抗体，58%的患者有抗核蛋白抗体。其他组的这些抗体均为阴性。接受氯丙嗪治疗的41例患者中有13例T淋巴细胞百分比低于正常水平。A组和B组的42例患者中有20例脾肿大，C组和D组的28例患者中无一例脾肿大。这项研究表明，大多数长期接受氯丙嗪治疗的患者会出现一种或多种免疫异常。
