Settnes O P, Singh G
Nord Vet Med. 1979 Oct;31(10):414-28.
Serum protein alterations in chickens contact-exposed to Marek's Disease Virus (MDV) were studied by crossed immunoelectrophoresis. Total protein values of infected chickens were initially, i.e. in the 4th week, low and later not significantly changed from those of the controls. In all infected chickens a significant increase was seen in the IgG components. Three of 6 infected chickens showing a prolonged period of clinical illness presented the most pronounced changes in other serum proteins, moderate or drastic decrease of albumin and alpha-1 lipoproptein and marked increase of arc 24 glycoprotein. Ceruloplasmin and C3 complement beta-1-C and beta-1-A were also increased in infected chickens. No such changes were seen in sera from control chickens. The significance of these changes with reference to previous work and induced pathology is discussed.
通过交叉免疫电泳研究了接触感染马立克氏病病毒（MDV）的鸡的血清蛋白变化。感染鸡的总蛋白值最初，即在第4周时较低，随后与对照组相比无显著变化。在所有感染鸡中，IgG成分显著增加。6只出现临床疾病持续期延长的感染鸡中有3只在其他血清蛋白方面呈现出最明显的变化，白蛋白和α-1脂蛋白中度或急剧下降，弧24糖蛋白显著增加。感染鸡的铜蓝蛋白和C3补体β-1-C和β-1-A也增加。对照鸡的血清中未观察到此类变化。结合先前的研究工作和诱发的病理学讨论了这些变化的意义。
