Melzacka M, Wiszniowska G, Daniel W, Vetulani J
Pol J Pharmacol Pharm. 1979 Jul-Aug;31(4):387-91.
Haloperidol did not change significantly the rate of penetration of apomorphine to three investigated structures of the rat brain: striatum, limbic forebrain and cerebellum. It depressed, however, significantly the accumulation of apomorphine in the striatum and limbic forebrain; in the cerebellum, in which the accumulation of apomorphine was very low, haloperidol did not change it. In haloperidol-pretreated rats the pattern of elimination of apomorphine from the striatum changed, revealing the presence of two compartments; this was not observed in the limbic forebrain, from which the elimination was linear, both in the presence and absence of haloperidol.
氟哌啶醇对阿扑吗啡进入大鼠脑的三个研究结构（纹状体、边缘前脑和小脑）的渗透率没有显著影响。然而，它显著降低了阿扑吗啡在纹状体和边缘前脑中的蓄积；在小脑中，阿扑吗啡的蓄积非常低，氟哌啶醇对其没有影响。在经氟哌啶醇预处理的大鼠中，纹状体中阿扑吗啡的消除模式发生了变化，显示出存在两个区室；在边缘前脑中未观察到这种情况，无论有无氟哌啶醇，边缘前脑中阿扑吗啡的消除都是线性的。
