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相似文献

1
Failure of treatment in chronic dermatophyte infections.慢性皮肤癣菌感染的治疗失败
Postgrad Med J. 1979 Sep;55(647):608-10. doi: 10.1136/pgmj.55.647.608.
2
Chronic dermatophyte infections. I. Clinical and mycological features.慢性皮肤癣菌感染。I. 临床和真菌学特征。
Br J Dermatol. 1982 Jan;106(1):1-7. doi: 10.1111/j.1365-2133.1982.tb00895.x.
3
Chronic urticaria in association with dermatophytosis. Response to the administration of griseofulvin.慢性荨麻疹合并皮肤癣菌病。对服用灰黄霉素的反应。
Arch Dermatol. 1967 Apr;95(4):400-1.
4
Dermatophyte infections in hereditary palmo-plantar keratoderma. Frequency and therapy.
Dermatologica. 1984;168(5):238-41. doi: 10.1159/000249711.
5
Imbalance of immune responses in patients with chronic and widespread fungal skin infection.慢性广泛性皮肤真菌感染患者的免疫反应失衡。
Clin Exp Dermatol. 1995 Sep;20(5):390-4. doi: 10.1111/j.1365-2230.1995.tb01355.x.
6
[Resistance to griseofulvin (author's transl)].对灰黄霉素的耐药性（作者译）
Z Hautkr. 1981 Oct 15;56(20):1326-33.
7
Immune response and host resistance of humans to dermatophyte infection.
J Am Acad Dermatol. 1993 May;28(5 Pt 1):S12-S18. doi: 10.1016/s0190-9622(09)80302-2.
8
Treatment of chronic dermatophyte infections. The use of ketoconazole in griseofulvin treatment failures.慢性皮肤癣菌感染的治疗。酮康唑在灰黄霉素治疗失败病例中的应用。
Clin Exp Dermatol. 1982 Nov;7(6):611-7. doi: 10.1111/j.1365-2230.1982.tb02485.x.
9
Oral therapy with ketoconazole for dermatophyte infections unresponsive to griseofulvin.酮康唑口服治疗对灰黄霉素无反应的皮肤癣菌感染。
Rev Infect Dis. 1980 Jul-Aug;2(4):578-81. doi: 10.1093/clinids/2.4.578.
10
Immediate and delayed hypersensitivity in chronic dermatophytosis.慢性皮肤癣菌病中的速发型和迟发型超敏反应。
Arch Dermatol. 1976 Jan;112(1):40-2.

引用本文的文献

1
Clinicomycological Profile of Pediatric Dermatophytoses: An Observational Study.儿童皮肤癣菌病的临床真菌学概况：一项观察性研究。
Indian Dermatol Online J. 2022 May 5;13(3):361-365. doi: 10.4103/idoj.idoj_235_21. eCollection 2022 May-Jun.
2
Total serum IgE level in patients of dermatophytosis and its association with various clinical parameters.皮肤癣菌病患者的血清总IgE水平及其与各种临床参数的关联。
Indian J Dermatol Venereol Leprol. 2021 Mar-Apr;87(2):290-292. doi: 10.25259/IJDVL_1043_19.
3
Scenario of chronic dermatophytosis: an Indian study.慢性皮肤癣菌病病例：一项印度的研究。
Mycopathologia. 1997;140(3):129-35. doi: 10.1023/a:1006843418759.
4
Class-specific antibody in human dermatophytosis reactive with Trichophyton rubrum derived antigen.
Mycopathologia. 1994 Aug;127(2):83-8. doi: 10.1007/BF01103063.
5
Cutaneous defenses against dermatophytes and yeasts.皮肤对皮肤癣菌和酵母菌的防御。
Clin Microbiol Rev. 1995 Jul;8(3):317-35. doi: 10.1128/CMR.8.3.317.
6
Treating fungal infections.治疗真菌感染。
Br Med J. 1980 Mar 8;280(6215):668-9.
7
Systemic opportunistic fungal infections.系统性机会性真菌感染。
Postgrad Med J. 1979 Sep;55(647):593-4. doi: 10.1136/pgmj.55.647.593.

本文引用的文献

1
In vitro studies of the antifungal antibiotic griseofulvin.
J Invest Dermatol. 1959 Dec;33:403-18. doi: 10.1038/jid.1959.164.
2
Effect of prolonged griseofulvin administration on liver, hematopoietic system, and kidney.长期服用灰黄霉素对肝脏、造血系统及肾脏的影响。
Arch Dermatol. 1960 May;81:760-5. doi: 10.1001/archderm.1960.03730050116020.
3
Effective use of griseofulvin.灰黄霉素的有效应用。
Arch Dermatol. 1963 Feb;87:176-8. doi: 10.1001/archderm.1963.01590140038006.
4
Experimental ringworm in guinea pigs: oral treatment with griseofulvin.豚鼠实验性癣病：用灰黄霉素进行口服治疗。
Nature. 1958 Aug 16;182(4633):476-7. doi: 10.1038/182476a0.
5
Griseofulvin levels in stratum corneum. Study after oral administration in man.角质层中的灰黄霉素水平。人体口服给药后的研究。
Arch Dermatol. 1972 Sep;106(3):344-8.
6
Immunologic susceptibility to chronic dermatophytosis.慢性皮肤癣菌病的免疫易感性。
Arch Dermatol. 1974 Aug;110(2):213-20.
7
Immunological reactivity in dermatophytosis.皮肤癣菌病中的免疫反应性。
Br J Dermatol. 1974 Jan;90(1):1-8.
8
Cell-mediated (delayed) hypersensitivity in patients with summer hay-fever.夏季花粉症患者的细胞介导（迟发型）超敏反应。
Lancet. 1969 Dec 13;2(7633):1269-72. doi: 10.1016/s0140-6736(69)90807-1.
9
Immunology of dermatophytes and dermatophytosis.皮肤癣菌与皮肤癣菌病的免疫学
Bacteriol Rev. 1974 Jun;38(2):222-50. doi: 10.1128/br.38.2.222-250.1974.
10
Epidermal activity in annular dermatophytosis.体癣中的表皮活动
Arch Dermatol. 1976 Apr;112(4):485-8.

慢性皮肤癣菌感染的治疗失败

Failure of treatment in chronic dermatophyte infections.

作者信息

Hay R J

出版信息

Postgrad Med J. 1979 Sep;55(647):608-10. doi: 10.1136/pgmj.55.647.608.

DOI:10.1136/pgmj.55.647.608
PMID:523349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2425655/
Abstract

A proportion of dermatophyte infections fail to respond to normally adequate courses of griseofulvin and topical antifungal therapy. The organism Trichophyton rubrum was isolated from 96% of 50 patients studied, but no instances of in vitro resistance were seen. Of these patients, 57% had an underlying condition, commonly hay fever/asthma, atopic eczema, collagen disease or ichthyosis. Defective delayed type hypersensitivity responses and leucocyte migration inhibition to the specific antigen, trichophytin, were demonstrated. Immediate type hypersensitivity was seen in 58% and this was partially suppressible with chlorpheniramine and cimetidine. The relationship between these abnormalities and failure of treatment is discussed.

摘要

一部分皮肤癣菌感染对通常足够疗程的灰黄霉素和局部抗真菌治疗无反应。从50例研究患者中的96%分离出红色毛癣菌，但未发现体外耐药情况。这些患者中，57%有基础疾病，常见的有花粉症/哮喘、特应性湿疹、胶原病或鱼鳞病。已证实存在对特异性抗原癣菌素的迟发型超敏反应缺陷和白细胞迁移抑制。58%的患者出现速发型超敏反应，且可用氯苯那敏和西咪替丁部分抑制。讨论了这些异常与治疗失败之间的关系。