Hay R J
Br J Dermatol. 1982 Jan;106(1):1-7. doi: 10.1111/j.1365-2133.1982.tb00895.x.
One hundred and six patients with chronic dermatophytosis unresponsive to griseofulvin were studied. Trichophyton rubrum was the causative organism in 93% of cases. Chronic dermatophyte infections caused by organisms other than T. rubrum occurred predominantly, but not exclusively, in patients with underlying diseases. Forty-nine percent of the patients had a personal or family history of atopy but other abnormalities included disorders of keratinization, collagen vascular disease and systemic steroid therapy. The commonest sites of infection were the palms and soles, as opposed to toe webs or groins in control patients with griseofulvin-responsive dermatophyte infections. A significant proportion of chronically infected patients had raised IgE levels. Only 11% of the chronically infected group showed delayed hypersensitivity responses to intradermal trichophytin but 58% showed immediate hypersensitivity responses to trichophytin as well as other fungal and non-fungal allergens.
对106例对灰黄霉素无反应的慢性皮肤癣菌病患者进行了研究。红色毛癣菌是93%病例中的致病生物体。由红色毛癣菌以外的生物体引起的慢性皮肤癣菌感染主要但并非仅发生于患有基础疾病的患者。49%的患者有个人或家族特应性病史，但其他异常包括角化紊乱、胶原血管病和全身类固醇治疗。感染的最常见部位是手掌和脚底，这与对灰黄霉素有反应的皮肤癣菌感染对照患者的趾间或腹股沟部位不同。相当一部分慢性感染患者的IgE水平升高。慢性感染组中只有11%的患者对皮内注射癣菌素表现出迟发型超敏反应，但58%的患者对癣菌素以及其他真菌和非真菌过敏原表现出速发型超敏反应。
