Rom-Bugoslavaskaia E S, Tikhonova E P, Ozerova M R, Levchenko T P, Marim'ian L S
Probl Endokrinol (Mosk). 1979 Nov-Dec;25(6):11-6.
In the blood of patients (104) with diabetes mellitus of various severity some energy metabolic indices (lactate, pyruvate, nonesterified fatty acids, and in some patients also glycogen and glycogenolytic activity of the blood), tissue oxygen tension and immunoreactive insulin were studied simultaneously. The glycogen content, a and b phosphorylase activity were determined in the liver and the skeletal muscles, and lactate, glycogen, and pyruvate in the blood of animals with experimentally induced diabetes mellitus (alloxan and immune diabetes). Changes in the energy metabolism were revealed in all forms of diabetes mellitus: in hyperinsulinism accompanying early forms of diabetes mellitus there was activation of anaerobic processes and tissue hyperoxygenation, and at the late stages of the disease a tendency to tissue hypoxia. Experimental diabetes was accompanied by glycogen reduction in the skeletal muscles together with the growth of b phosphorylase activity. This could be due to the reduction of glucose-6-phosphate in the muscles and to a disturbed activity of the other systems regulating glycogen metabolism.
对不同严重程度的糖尿病患者（104例）血液中的一些能量代谢指标（乳酸、丙酮酸、非酯化脂肪酸，部分患者还包括血液中的糖原和糖原分解活性）、组织氧张力和免疫反应性胰岛素进行了同步研究。测定了实验性诱导糖尿病（四氧嘧啶性和免疫性糖尿病）动物肝脏和骨骼肌中的糖原含量、α和β磷酸化酶活性，以及血液中的乳酸、糖原和丙酮酸。在所有类型的糖尿病中均发现了能量代谢的变化：在糖尿病早期形式伴随的高胰岛素血症中，无氧过程被激活且组织出现高氧状态，而在疾病后期则有组织缺氧的倾向。实验性糖尿病伴随着骨骼肌中糖原减少以及β磷酸化酶活性增加。这可能是由于肌肉中6-磷酸葡萄糖减少以及调节糖原代谢的其他系统活性紊乱所致。
